AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum.

AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum.

The beta-adrenergic receptor/cyclic AMP/protein kinase A (PKA) signalling pathway regulates heart rate and contractility. Here, we identified a supramolecular complex consisting of the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA2), its negative regulator phospholamban (PLN), the A-kinase anchoring p...

Full description

Bibliographic Details
Main Authors:	Lygren, B, Carlson, C, Santamaria, K, Lissandron, V, McSorley, T, Litzenberg, J, Lorenz, D, Wiesner, B, Rosenthal, W, Zaccolo, M, Taskén, K, Klussmann, E
Format:	Journal article
Language:	English
Published:	2007

Similar Items

Ca2+-mobility in the sarcoplasmic reticulum of ventricular myocytes is low.
by: Swietach, P, et al.
Published: (2008)

Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling.
by: Tocchetti, C, et al.
Published: (2007)

Effects of Acute Exercise and Training on the Sarcoplasmic Reticulum Ca2+ Release and Uptake Rates in Highly Trained Endurance Athletes
by: Kasper Degn Gejl, et al.
Published: (2020-07-01)

Sarcoplasmic Reticulum-Mitochondria Kissing in Cardiomyocytes: Ca2+, ATP, and Undisclosed Secrets
by: Michela Rossini, et al.
Published: (2020-06-01)

Unbalance Between Sarcoplasmic Reticulum Ca2 + Uptake and Release: A First Step Toward Ca2 + Triggered Arrhythmias and Cardiac Damage
by: Marilén Federico, et al.
Published: (2020-01-01)

Sarcoplasmic Reticulum Calcium Release Is Required for Arrhythmogenesis in the Mouse
by: Andrew G. Edwards, et al.
Published: (2021-10-01)

Role of Reduced Sarco-Endoplasmic Reticulum Ca2+-ATPase Function on Sarcoplasmic Reticulum Ca2+ Alternans in the Intact Rabbit Heart
by: Lianguo Wang, et al.
Published: (2021-05-01)

Correction: A Novel Artificial MicroRNA Expressing AAV Vector for Phospholamban Silencing in Cardiomyocytes Improves Ca Uptake into the Sarcoplasmic Reticulum.
Published: (2014-01-01)

Mitochondrial and Sarcoplasmic Reticulum Interconnection in Cardiac Arrhythmia
by: Felipe Salazar-Ramírez, et al.
Published: (2021-01-01)

FKBP12 Depletion Leads to Loss of Sarcoplasmic Reticulum Ca2+ Stores in Rat Vas Deferens
by: Christianne B.V. Scaramello, et al.
Published: (2009-01-01)

Spaceflight increases sarcoplasmic reticulum Ca2+ leak and this cannot be counteracted with BuOE treatment
by: Jessica L. Braun, et al.
Published: (2024-07-01)

Targeting calcium regulators as therapy for heart failure: focus on the sarcoplasmic reticulum Ca-ATPase pump
by: Changwon Kho
Published: (2023-07-01)

CaMKII activation in early diabetic hearts induces altered sarcoplasmic reticulum-mitochondria signaling
by: Marilen Federico, et al.
Published: (2021-10-01)

Ca2+-Releasing Effect of Cerivastatin on the Sarcoplasmic Reticulum of Mouse and Rat Skeletal Muscle Fibers
by: Ryotaku Inoue, et al.
Published: (2003-01-01)

Correction: A Novel Artificial MicroRNA Expressing AAV Vector for Phospholamban Silencing in Cardiomyocytes Improves Ca2+ Uptake into the Sarcoplasmic Reticulum
Published: (2014-01-01)

The sarcoplasmic reticulum plays a central role in local pH-induced changes to cytosolic Ca2+
by: Swietach, P, et al.
Published: (2007)

Sarcoplasmic Reticulum from Horse Gluteal Muscle Is Poised for Enhanced Calcium Transport
by: Joseph M. Autry, et al.
Published: (2021-11-01)

Neuronostatin Attenuates Myocardial Contractile Function through Inhibition of Sarcoplasmic Reticulum Ca2+-ATPase in Murine Heart
by: Xiaoling Zhu, et al.
Published: (2014-06-01)

Alteration of Sarcoplasmic Reticulum Ca2+ Release in Skeletal Muscle from Calpain 3-Deficient Mice
by: Govindan Dayanithi, et al.
Published: (2009-01-01)

Isolation of the Sarcoplasmic Reticulum Ca<sup>2+</sup>-ATPase from Rabbit Fast-Twitch Muscle
by: Miguel A. Rivera-Morán, et al.
Published: (2023-10-01)

Crosstalk between mitochondrial and sarcoplasmic reticulum Ca2+ cycling modulates cardiac pacemaker cell automaticity.
by: Yael Yaniv, et al.
Published: (2012-01-01)

Impaired Sarcoplasmic Reticulum Calcium Uptake and Release Promote Electromechanically and Spatially Discordant Alternans: A Computational Study
by: Seth H. Weinberg
Published: (2016-01-01)

Impaired Sarcoplasmic Reticulum Calcium Uptake and Release Promote Electromechanically and Spatially Discordant Alternans: A Computational Study
by: Seth H. Weinberg
Published: (2016-06-01)

Inhibition of the sarcoplasmic reticulum Ca2+ pump with thapsigargin to estimate the contribution of Na+-Ca2+ exchange to ventricular myocyte relaxation
by: Bassani R.A., et al.
Published: (2003-01-01)

Energy interconversion by the sarcoplasmic reticulum Ca2+-ATPase: ATP hydrolysis, Ca2+ transport, ATP synthesis and heat production
by: LEOPOLDO DE MEIS
Published: (2000-09-01)

Modulation of sarcoplasmic reticulum calcium release by calsequestrin in cardiac myocytes
by: SANDOR GYÖRKE, et al.
Published: (2004-01-01)

Regulation by thyroid hormone of the expression of sarcoplasmic reticulum Ca2+-ATPaSe Isoforms in rat skeletal muscle
by: , LINDEN, Cornelis Gerardus van der, et al.
Published: (1994)

Reconstitution of a Ca2+-transporting ATPase system from triton X-100-solubilized sarcoplasmic reticulum.
by: Chiesi, M, et al.
Published: (1978)

Polymorphic variants of genes encoding Ca(2+)-transporting sarcoplasmic reticulum proteins in the progression of chronic heart failure
by: E. F. Muslimova, et al.
Published: (2019-11-01)

Ca<sup>2+</sup> Channels Mediate Bidirectional Signaling between Sarcolemma and Sarcoplasmic Reticulum in Muscle Cells
by: Guillermo Avila, et al.
Published: (2019-12-01)

IgE-dependent human basophil responses are inversely associated with the sarcoplasmic reticulum Ca2+-ATPase (SERCA)
by: Anette T. Hansen Selnø, et al.
Published: (2023-01-01)

A secretory pathway kinase regulates sarcoplasmic reticulum Ca2+ homeostasis and protects against heart failure
by: Adam J Pollak, et al.
Published: (2018-12-01)

Electrostatic interactions between single arginine and phospholipids modulate physiological properties of sarcoplasmic reticulum Ca2+-ATPase
by: Kazuo Yamasaki, et al.
Published: (2022-07-01)

PKC Inhibits Sec61 Translocon-Mediated Sarcoplasmic Reticulum Ca2+ Leak in Smooth Muscle Cells
by: Adan Dagnino-Acosta, et al.
Published: (2022-06-01)

Excitation-contraction coupling in zebrafish ventricular myocardium is regulated by trans-sarcolemmal Ca2+ influx and sarcoplasmic reticulum Ca2+ release.
by: Moritz Haustein, et al.
Published: (2015-01-01)

Ca2+/calmodulin‐dependent kinase IIδC‐induced chronic heart failure does not depend on sarcoplasmic reticulum Ca2+ leak
by: Matthias Dewenter, et al.
Published: (2024-08-01)

Enhanced activity of multiple TRIC‐B channels: an endoplasmic reticulum/sarcoplasmic reticulum mechanism to boost counterion currents
by: O'Brien, F, et al.
Published: (2019)

Biophysical characterisation of the mechanisms regulating sarcoplasmic reticulum K+ channel gating
by: O'Brien, F
Published: (2015)

Photodynamic Inactivation of the Sarcoplasmic Reticulum Ca2+-ATPase by a Ruthenium Polypyridyl Complex Featuring π-Expansive Ligands
by: Gina Elena Giacomazzo, et al.
Published: (2025-01-01)

The Sarcoplasmic/Endoplasmic reticulum Ca2+-ATPase (SERCA) is present in pig sperm and modulates their physiology over liquid preservation
by: Ferran Garriga, et al.
Published: (2025-02-01)