Adverse drug reactions: definitions, diagnosis, and management.
We define an adverse drug reaction as "an appreciably harmful or unpleasant reaction, resulting from an intervention related to the use of a medicinal product, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2000
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| _version_ | 1797051178378330112 |
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| author | Edwards, I Aronson, J |
| author_facet | Edwards, I Aronson, J |
| author_sort | Edwards, I |
| collection | OXFORD |
| description | We define an adverse drug reaction as "an appreciably harmful or unpleasant reaction, resulting from an intervention related to the use of a medicinal product, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product." Such reactions are currently reported by use of WHO's Adverse Reaction Terminology, which will eventually become a subset of the International Classification of Diseases. Adverse drug reactions are classified into six types (with mnemonics): dose-related (Augmented), non-dose-related (Bizarre), dose-related and time-related (Chronic), time-related (Delayed), withdrawal (End of use), and failure of therapy (Failure). Timing, the pattern of illness, the results of investigations, and rechallenge can help attribute causality to a suspected adverse drug reaction. Management includes withdrawal of the drug if possible and specific treatment of its effects. Suspected adverse drug reactions should be reported. Surveillance methods can detect reactions and prove associations. |
| first_indexed | 2024-03-06T18:16:14Z |
| format | Journal article |
| id | oxford-uuid:04b5c5ba-9a91-4875-b5e2-f74af1e4cd8f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:16:14Z |
| publishDate | 2000 |
| record_format | dspace |
| spelling | oxford-uuid:04b5c5ba-9a91-4875-b5e2-f74af1e4cd8f2022-03-26T08:53:15ZAdverse drug reactions: definitions, diagnosis, and management.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:04b5c5ba-9a91-4875-b5e2-f74af1e4cd8fEnglishSymplectic Elements at Oxford2000Edwards, IAronson, JWe define an adverse drug reaction as "an appreciably harmful or unpleasant reaction, resulting from an intervention related to the use of a medicinal product, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product." Such reactions are currently reported by use of WHO's Adverse Reaction Terminology, which will eventually become a subset of the International Classification of Diseases. Adverse drug reactions are classified into six types (with mnemonics): dose-related (Augmented), non-dose-related (Bizarre), dose-related and time-related (Chronic), time-related (Delayed), withdrawal (End of use), and failure of therapy (Failure). Timing, the pattern of illness, the results of investigations, and rechallenge can help attribute causality to a suspected adverse drug reaction. Management includes withdrawal of the drug if possible and specific treatment of its effects. Suspected adverse drug reactions should be reported. Surveillance methods can detect reactions and prove associations. |
| spellingShingle | Edwards, I Aronson, J Adverse drug reactions: definitions, diagnosis, and management. |
| title | Adverse drug reactions: definitions, diagnosis, and management. |
| title_full | Adverse drug reactions: definitions, diagnosis, and management. |
| title_fullStr | Adverse drug reactions: definitions, diagnosis, and management. |
| title_full_unstemmed | Adverse drug reactions: definitions, diagnosis, and management. |
| title_short | Adverse drug reactions: definitions, diagnosis, and management. |
| title_sort | adverse drug reactions definitions diagnosis and management |
| work_keys_str_mv | AT edwardsi adversedrugreactionsdefinitionsdiagnosisandmanagement AT aronsonj adversedrugreactionsdefinitionsdiagnosisandmanagement |