A single dose of anti-miR-122, RG-101, in CHC patients results in NK cell normalization with no effect on HCV-specific CD8+ T cell function

A single dose of anti-miR-122, RG-101, in CHC patients results in NK cell normalization with no effect on HCV-specific CD8+ T cell function

MicroRNA-122 (miR-122) is an important host factor for the hepatitis C virus. Treatment with RG-101, a GalNAc conjugated anti-miR-122 oligonucleotide, resulted in a significant viral load reduction in patients with chronic hepatitis C (CHC) infection. Here, we analyzed the effects of RG-101 therapy...

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Bibliographic Details
Main Authors: Stelma, F, van der Ree, M, Sinnige, M, Brown, A, Swadling, L, de Vree, J, Willemse, S, van der Valk, M, Grint, P, Neben, S, Klenerman, P, Barnes, E, Kootstra, N, Reesink, H
Format: Journal article
Published: Wiley 2017

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