Low-coverage sequencing cost-effectively detects known and novel variation in underrepresented populations

Low-coverage sequencing cost-effectively detects known and novel variation in underrepresented populations

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Genetic studies in underrepresented populations identify disproportionate numbers of novel associations. However, most genetic studies use genotyping arrays and sequenced reference panels that best capture variation most common in European ancestry populations. To compare data generation strategies...

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Main Authors: Martin, AR, Atkinson, EG, Chapman, SB, Stevenson, A, Stroud, RE, Abebe, T, Akena, D, Alemayehu, M, Ashaba, FK, Atwoli, L, Bowers, T, Chibnik, LB, Daly, MJ, DeSmet, T, Dodge, S, Fekadu, A, Ferriera, S, Gelaye, B, Gichuru, S, Injera, WE, James, R, Kariuki, SM, Kigen, G, Koenen, KC, Kwobah, E, Kyebuzibwa, J, Majara, L, Musinguzi, H, Mwema, RM, Neale, BM, Newman, CP, Newton, CRJC, Pickrell, JK, Ramesar, R, Shiferaw, W, Stein, DJ, Teferra, S, van der Merwe, C, Zingela, Z
Drugi avtorji: NeuroGAP-Psychosis Study Team
Format: Journal article
Jezik:English
Izdano: Elsevier 2021

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