Microscopic colitis: can it be qualitatively and quantitatively characterized?
This study reports the histological features helpful in diagnosing microscopic colitis. Rectal biopsy specimens from 14 patients with microscopic colitis, 14 with active ulcerative colitis and 14 without colonic inflammation were pooled and then assessed by three observers according to a predetermin...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1992
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| _version_ | 1826257354397581312 |
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| author | Fasoli, R Talbot, I Reid, M Prince, C Jewell, D |
| author_facet | Fasoli, R Talbot, I Reid, M Prince, C Jewell, D |
| author_sort | Fasoli, R |
| collection | OXFORD |
| description | This study reports the histological features helpful in diagnosing microscopic colitis. Rectal biopsy specimens from 14 patients with microscopic colitis, 14 with active ulcerative colitis and 14 without colonic inflammation were pooled and then assessed by three observers according to a predetermined protocol. Inter-observer agreement was good except for Paneth cell metaplasia and endocrine cell metaplasia. Compared with healthy tissue, microscopic colitis showed a significant (p less than 0.05) increase in chronic inflammatory cells and a depletion of goblet cells but these changes were less pronounced than those seen in ulcerative colitis (p less than 0.05). In contrast to ulcerative colitis, microscopic colitis was associated with a more marked infiltration with eosinophils and an increase in intra-epithelial lymphocytes. These results show that microscopic colitis can be distinguished both from normal colonic tissue and from ulcerative colitis. |
| first_indexed | 2024-03-06T18:16:52Z |
| format | Journal article |
| id | oxford-uuid:04eaed36-44cb-492b-93f3-224e2c1bca5f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:16:52Z |
| publishDate | 1992 |
| record_format | dspace |
| spelling | oxford-uuid:04eaed36-44cb-492b-93f3-224e2c1bca5f2022-03-26T08:54:21ZMicroscopic colitis: can it be qualitatively and quantitatively characterized?Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:04eaed36-44cb-492b-93f3-224e2c1bca5fEnglishSymplectic Elements at Oxford1992Fasoli, RTalbot, IReid, MPrince, CJewell, DThis study reports the histological features helpful in diagnosing microscopic colitis. Rectal biopsy specimens from 14 patients with microscopic colitis, 14 with active ulcerative colitis and 14 without colonic inflammation were pooled and then assessed by three observers according to a predetermined protocol. Inter-observer agreement was good except for Paneth cell metaplasia and endocrine cell metaplasia. Compared with healthy tissue, microscopic colitis showed a significant (p less than 0.05) increase in chronic inflammatory cells and a depletion of goblet cells but these changes were less pronounced than those seen in ulcerative colitis (p less than 0.05). In contrast to ulcerative colitis, microscopic colitis was associated with a more marked infiltration with eosinophils and an increase in intra-epithelial lymphocytes. These results show that microscopic colitis can be distinguished both from normal colonic tissue and from ulcerative colitis. |
| spellingShingle | Fasoli, R Talbot, I Reid, M Prince, C Jewell, D Microscopic colitis: can it be qualitatively and quantitatively characterized? |
| title | Microscopic colitis: can it be qualitatively and quantitatively characterized? |
| title_full | Microscopic colitis: can it be qualitatively and quantitatively characterized? |
| title_fullStr | Microscopic colitis: can it be qualitatively and quantitatively characterized? |
| title_full_unstemmed | Microscopic colitis: can it be qualitatively and quantitatively characterized? |
| title_short | Microscopic colitis: can it be qualitatively and quantitatively characterized? |
| title_sort | microscopic colitis can it be qualitatively and quantitatively characterized |
| work_keys_str_mv | AT fasolir microscopiccolitiscanitbequalitativelyandquantitativelycharacterized AT talboti microscopiccolitiscanitbequalitativelyandquantitativelycharacterized AT reidm microscopiccolitiscanitbequalitativelyandquantitativelycharacterized AT princec microscopiccolitiscanitbequalitativelyandquantitativelycharacterized AT jewelld microscopiccolitiscanitbequalitativelyandquantitativelycharacterized |