Effects of mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channel.

Effects of mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channel.

1. We have investigated the mechanism of action of the novel anti-diabetic agent mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium (K(ATP)) channel. These possess a common pore-forming subunit, Kir6.2, and different regulatory sulphonylurea receptor...

Full description

Bibliographic Details
Main Authors:	Reimann, F, Proks, P, Ashcroft, F
Format:	Journal article
Language:	English
Published:	2001

Similar Items

Glimepiride block of Kir6.2/SUR1 Kir6.2/SUR2A and Kir6.2/SUR2A and Kir6.2/SUR2B K-ATP channels.
by: Ashcroft, F, et al.
Published: (2001)

Time-dependent activation of Kir6.2/SUR2A channels but not Kir6.2/SUR1 channels in the presence of ATP
by: Ashcroft, F, et al.
Published: (2001)

Time-dependent activation of KIR6.2/SUR2A channels but not KIR6.2/SUR1 channels in the presence of MgATP
by: Song, D, et al.
Published: (2001)

The N-terminus of Kir6.2 is involved in coupling to SUR1
by: Reimann, F, et al.
Published: (1999)

Kir6.2 mutations causing neonatal diabetes provide new insights into Kir6.2-SUR1 interactions.
by: Tammaro, P, et al.
Published: (2005)

Nucleotide modulation of pinacidil stimulation of the cloned K(ATP) channel Kir6.2/SUR2A.
by: Gribble, F, et al.
Published: (2000)

Structure-function studies of the fast gating kinetics of the cloned ATP-sensitive potassium channel, Kir6.2/SUR1
by: Proks, P, et al.
Published: (2001)

Focus on Kir6.2: a key component of the ATP-sensitive potassium channel.
by: Haider, S, et al.
Published: (2005)

Phentolamine block of KATP channels is mediated by Kir6.2.
by: Proks, P, et al.
Published: (1997)

A novel SUR1/Kir6.2 specific K-ATP channel opener
by: Dabrowski, M, et al.
Published: (2001)

Involvement of the N-terminus of Kir6.2 in the inhibition of the KATP channel by ATP.
by: Proks, P, et al.
Published: (1999)

An in-frame deletion in Kir6.2 (KCNJ11) causing neonatal diabetes reveals a site of interaction between Kir6.2 and SUR1.
by: Craig, T, et al.
Published: (2009)

Involvement of the n-terminus of Kir6.2 in coupling to the sulphonylurea receptor.
by: Reimann, F, et al.
Published: (1999)

Mapping the architecture of the ATP-binding site of Kir6.2
by: Dabrowski, M, et al.
Published: (2002)

The role of lysine 185 in the kir6.2 subunit of the ATP-sensitive channel in channel inhibition by ATP.
by: Reimann, F, et al.
Published: (1999)

Mutations within the P-loop of Kir6.2 modulate the intraburst kinetics of the ATP-sensitive potassium channel.
by: Proks, P, et al.
Published: (2001)

The Kir6.2-F333I mutation differentially modulates K-ATP channels composed of SUR1 or SUR2 subunits
by: Tammaro, P, et al.
Published: (2007)

The Kir6.2-F333I mutation differentially modulates K ATP channels composed of SUR1 and SUR2 subunits
by: Tammaro, P, et al.
Published: (2007)

Identification of residues contributing to the ATP binding site of Kir6.2.
by: Trapp, S, et al.
Published: (2003)

Pyridine nucleotide regulation of the KATP channel Kir6.2/SUR1 expressed in Xenopus oocytes.
by: Dabrowski, M, et al.
Published: (2003)

A mutation in the ATP-binding site of the Kir6.2 subunit of the KATP channel alters coupling with the SUR2A subunit.
by: Tammaro, P, et al.
Published: (2007)

Mapping the architecture of the ATP-binding site of the KATP channel subunit Kir6.2.
by: Dabrowski, M, et al.
Published: (2004)

The Kir6.2-F333I mutation differentially modulates KATP channels composed of SUR1 or SUR2 subunits.
by: Tammaro, P, et al.
Published: (2007)

Screening for mutations in the Kir6.2 subunit of the beta-cell K-ATP channel
by: Sakura, H, et al.
Published: (1996)

Overlapping distribution of K(ATP) channel-forming Kir6.2 subunit and the sulfonylurea receptor SUR1 in rodent brain.
by: Karschin, C, et al.
Published: (1997)

Direct photoaffinity labeling of the Kir6.2 subunit of the ATP-sensitive K+ channel by 8-azido-ATP.
by: Tanabe, K, et al.
Published: (1999)

Behavioral phenotyping of mice lacking the K ATP channel subunit Kir6.2.
by: Deacon, R, et al.
Published: (2006)

Behavioral phenotyping of mice lacking the K ATP channel subunit Kir6.2.
by: Deacon, R, et al.
Published: (2006)

Interaction of the cytosolic domains of the Kir6.2 subunit of the K(ATP) channel is modulated by sulfonylureas.
by: Lippiat, J, et al.
Published: (2002)

Functional analysis of a structural model of the ATP-binding site of the KATP channel Kir6.2 subunit.
by: Antcliff, J, et al.
Published: (2005)

Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor.
by: Tucker, S, et al.
Published: (1997)

Filter flexibility in a mammalian K channel: models and simulations of Kir6.2 mutants.
by: Capener, C, et al.
Published: (2003)

3-D structural and functional characterization of the purified KATP channel complex Kir6.2-SUR1.
by: Mikhailov, M, et al.
Published: (2005)

Direct photoaffinity labeling of Kir6.2 by [gamma-(32)P]ATP-[gamma]4-azidoanilide.
by: Tanabe, K, et al.
Published: (2000)

Mapping of the physical interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2.
by: Tucker, S, et al.
Published: (1999)

Multiple sites of interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2.
by: Jones, P, et al.
Published: (2001)

Parametrisation of the free energy of ATP binding to wild-type and mutant Kir6.2 potassium channels.
by: Moran, O, et al.
Published: (2013)

Kir6.2-dependent high-affinity repaglinide binding to beta-cell K(ATP) channels.
by: Hansen, A, et al.
Published: (2005)

Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes.
by: Gloyn, A, et al.
Published: (2004)

Reduced expression of Kir6.2/SUR2A subunits explains KATP deficiency in K+-depleted rats.
by: Tricarico, D, et al.
Published: (2008)