Macrophages and the hypoxic tumour microenvironment.
One characteristic of solid tumour tissue is the presence of large numbers of tumour-associated macrophages. These migrate down gradients of chemo-attractive agents to accumulate within hypoxic and / or necrotic areas where they are generally related to poor clinical prognosis. In this review we wil...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2007
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| _version_ | 1826257361236393984 |
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| author | Knowles, H Harris, A |
| author_facet | Knowles, H Harris, A |
| author_sort | Knowles, H |
| collection | OXFORD |
| description | One characteristic of solid tumour tissue is the presence of large numbers of tumour-associated macrophages. These migrate down gradients of chemo-attractive agents to accumulate within hypoxic and / or necrotic areas where they are generally related to poor clinical prognosis. In this review we will discuss the molecular mechanisms that underlie recruitment of macrophages into tumours and their pro-tumourigenic activities with respect to stimulation of angiogenesis, lymphangiogenesis, tumour cell migration, metastasis and immuno-suppression. The potential of macrophage-related anticancer therapies will be discussed in the light of this phenotype. |
| first_indexed | 2024-03-06T18:16:58Z |
| format | Journal article |
| id | oxford-uuid:04f1473d-f1aa-4b47-b921-3e5d94f62041 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:16:58Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:04f1473d-f1aa-4b47-b921-3e5d94f620412022-03-26T08:54:28ZMacrophages and the hypoxic tumour microenvironment.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:04f1473d-f1aa-4b47-b921-3e5d94f62041EnglishSymplectic Elements at Oxford2007Knowles, HHarris, AOne characteristic of solid tumour tissue is the presence of large numbers of tumour-associated macrophages. These migrate down gradients of chemo-attractive agents to accumulate within hypoxic and / or necrotic areas where they are generally related to poor clinical prognosis. In this review we will discuss the molecular mechanisms that underlie recruitment of macrophages into tumours and their pro-tumourigenic activities with respect to stimulation of angiogenesis, lymphangiogenesis, tumour cell migration, metastasis and immuno-suppression. The potential of macrophage-related anticancer therapies will be discussed in the light of this phenotype. |
| spellingShingle | Knowles, H Harris, A Macrophages and the hypoxic tumour microenvironment. |
| title | Macrophages and the hypoxic tumour microenvironment. |
| title_full | Macrophages and the hypoxic tumour microenvironment. |
| title_fullStr | Macrophages and the hypoxic tumour microenvironment. |
| title_full_unstemmed | Macrophages and the hypoxic tumour microenvironment. |
| title_short | Macrophages and the hypoxic tumour microenvironment. |
| title_sort | macrophages and the hypoxic tumour microenvironment |
| work_keys_str_mv | AT knowlesh macrophagesandthehypoxictumourmicroenvironment AT harrisa macrophagesandthehypoxictumourmicroenvironment |