Synthetic studies towards sesquiterpenoids
<p><strong>Chapter 1</strong> explores synthetic efforts carried out during this project towards α-bulnesene. Several radical cyclisation methods are discussed for constructing the 5,7-fused bicyclic framework. A concise and enantiospecific route to 5-epi-α-bulnesene, combining a n...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
2023
|
| Subjects: |
| Summary: | <p><strong>Chapter 1</strong> explores synthetic efforts carried out during this project towards α-bulnesene. Several radical cyclisation methods are discussed for constructing the 5,7-fused bicyclic framework. A concise and enantiospecific route to 5-epi-α-bulnesene, combining a new reductive rearrangement method, is presented.</p>
<p><strong>Chapter 2</strong> focuses on the total synthesis of daphnenoid A. A unique strategy towards this cage-like tetracyclic structure is developed via an intramolecular Diels–Alder reaction and a 20-step synthesis leading to an advanced intermediate to daphnenoid A is presented.</p> |
|---|