An epitope-specific LGI1-autoantibody enhances neuronal excitability by modulating Kv1.1 channel

An epitope-specific LGI1-autoantibody enhances neuronal excitability by modulating Kv1.1 channel

Leucine-rich Glioma-Inactivated protein 1 (LGI1) is expressed in the central nervous system and its genetic loss of function is associated with epileptic disorders. Additionally, patients with LGI1-directed autoantibodies have frequent focal seizures as a key feature of their disease. LGI1 is compos...

Descrizione completa

Dettagli Bibliografici
Autori principali:	Extrémet, J, El Far, O, Ankri, N, Irani, SR, Debanne, D, Russier, M
Natura:	Journal article
Lingua:	English
Pubblicazione:	MDPI 2022

Documenti analoghi

An Epitope-Specific LGI1-Autoantibody Enhances Neuronal Excitability by Modulating Kv1.1 Channel
di: Johanna Extrémet, et al.
Pubblicazione: (2022-08-01)

CXCL13 levels and autoantibody epitope specificities in LGI1-autoantibody syndromes
di: Michael, S, et al.
Pubblicazione: (2019)

Patient-derived antibodies reveal the subcellular distribution and heterogeneous interactome of LGI1
di: Ramirez-Franco, J, et al.
Pubblicazione: (2022)

CXCL13 levels in LGI1-and CASPR2-autoantibody syndromes
di: Michael, S, et al.
Pubblicazione: (2019)

Stop testing for autoantibodies to the VGKC-complex: only request LGI1 and CASPR2
di: Michael, S, et al.
Pubblicazione: (2020)

Comparative effects of domain-specific human monoclonal antibodies against LGI1 on neuronal excitability
di: Sell, J, et al.
Pubblicazione: (2023)

The downregulation of Kv1 channels in Lgi1−/− mice is accompanied by a profound modification of its interactome and a parallel decrease in Kv2 channels
di: Jorge Ramirez-Franco, et al.
Pubblicazione: (2024-06-01)

Distinctive binding properties of human monoclonal LGI1 autoantibodies determine pathogenic mechanisms
di: Ramberger, M, et al.
Pubblicazione: (2020)

The role of axonal Kv1 channels in CA3 pyramidal cell excitability
di: Sylvain Rama, et al.
Pubblicazione: (2017-03-01)

A patient-derived mutation of epilepsy-linked LGI1 increases seizure susceptibility through regulating Kv1.1
di: Lin Zhou, et al.
Pubblicazione: (2023-02-01)

A fast Markovian method for modeling channel noise in neurons
di: Norbert Ankri, et al.
Pubblicazione: (2023-06-01)

Inverse Modulation of Neuronal Kv12.1 and Kv11.1 Channels by 4-Aminopyridine and NS1643
di: Marlen Dierich, et al.
Pubblicazione: (2018-01-01)

LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11
di: Koji Sagane, Yasushi Ishihama, Hachiro Sugimoto
Pubblicazione: (2008-01-01)

Voltage-gated potassium channel (Kv1) autoantibodies in patients with chagasic gut dysmotility and distribution of Kv1 channels in human enteric neuromusculature (autoantibodies in GI dysmotility)
di: Hubball, A, et al.
Pubblicazione: (2012)

Tonic seizures: a diagnostic clue of anti-LGI1 encephalitis?
di: Irani, SR, et al.
Pubblicazione: (2011)

Kv1.1 channels mediate network excitability and feed-forward inhibition in local amygdala circuits
di: Samrat Thouta, et al.
Pubblicazione: (2021-07-01)

LGI1 expression and human brain asymmetry: insights from patients with LGI1-antibody encephalitis
di: Jang, Y, et al.
Pubblicazione: (2018)

Kv1.1 contributes to a rapid homeostatic plasticity of intrinsic excitability in CA1 pyramidal neurons in vivo
di: Peter James Morgan, et al.
Pubblicazione: (2019-11-01)

Improving clinical practice with an old friend from the neuroimmunology toolkit: acute corticosteroids in LGI1 antibody encephalitis
di: Irani, SR
Pubblicazione: (2021)

Case Report: Anti-LGI1 Limbic Encephalitis Associated With Anti-thyroid Autoantibodies
di: Ricardo Otiniano-Sifuentes, et al.
Pubblicazione: (2021-01-01)

LGI1 expression and human brain asymmetry: insights from patients with LGI1-antibody encephalitis
di: Yoonhyuk Jang, et al.
Pubblicazione: (2018-09-01)

Immunotherapy-responsive chorea as the presenting feature of LGI1-antibody encephalitis.
di: Tofaris, G, et al.
Pubblicazione: (2012)

Dysregulation of the hippocampal neuronal network by LGI1 auto-antibodies.
di: Elodie Fels, et al.
Pubblicazione: (2022-01-01)

Thymoma-associated anti-LGI1 encephalitis and myasthenia gravis: A unique combination with autoantibodies
di: Akane Satake, et al.
Pubblicazione: (2022-06-01)

‘Less contented as a person’: an update from the LGI1-QoL study
di: Binks, S, et al.
Pubblicazione: (2019)

Faciobrachial dystonic seizures precede Lgi1 antibody limbic encephalitis.
di: Irani, SR, et al.
Pubblicazione: (2011)

Positive LGI1 Antibodies in CSF and Relapse Relate to Worse Outcome in Anti-LGI1 Encephalitis
di: Li-li Cui, et al.
Pubblicazione: (2021-12-01)

Vgkc is dead: long live lgi1- and caspr2-antibodies. intracellular and non-neuronal targets of voltage-gated potassium channel complex antibodies
di: Lang, B, et al.
Pubblicazione: (2017)

LGI1, CASPR2 and related antibodies: a molecular evolution of the phenotypes
di: Binks, S, et al.
Pubblicazione: (2017)

Hydrogen sulfide regulates hippocampal neuron excitability via S-sulfhydration of Kv2.1
di: Mark L. Dallas, et al.
Pubblicazione: (2021-04-01)

Distinct HLA associations of LGI1 and CASPR2-antibody diseases
di: Binks, S, et al.
Pubblicazione: (2018)

LGI1-antibody encephalitis is characterised by frequent, multifocal clinical and subclinical seizures
di: Aurangzeb, S, et al.
Pubblicazione: (2017)

Intrathecal B cell activation in LGI1-antibody encephalitis
di: Lehmann-Horn, K, et al.
Pubblicazione: (2020)

Mechanisms of disease perpetuation and pathogenesis in autoantibody-mediated epilepsies with a focus on LGI1- and CASPR2-related syndromes
di: Michael, S
Pubblicazione: (2022)

Tuning Scorpion Toxin Selectivity: Switching From KV1.1 to KV1.3
di: Andrei M. Gigolaev, et al.
Pubblicazione: (2020-07-01)

Immunotherapy responsive neuropathic pain associated with LGI1 and CASPR2 antibodies
di: Ramanathan, S, et al.
Pubblicazione: (2021)

LGI1-antibody associated epilepsy successfully treated in the outpatient setting
di: Uribe-San-Martín, R, et al.
Pubblicazione: (2020)

Hippocampal epileptogenesis in LGI1, CASPR2 and GABABR antibodies: preliminary findings
di: Romoli, M, et al.
Pubblicazione: (2020)

Clonal hematopoiesis in LGI1‐antibody encephalitis
di: Soo Jean Shin, et al.
Pubblicazione: (2024-10-01)

Psychiatric Manifestation of Anti-LGI1 Encephalitis
di: Dominique Endres, et al.
Pubblicazione: (2020-06-01)