An epitope-specific LGI1-autoantibody enhances neuronal excitability by modulating Kv1.1 channel

An epitope-specific LGI1-autoantibody enhances neuronal excitability by modulating Kv1.1 channel

Leucine-rich Glioma-Inactivated protein 1 (LGI1) is expressed in the central nervous system and its genetic loss of function is associated with epileptic disorders. Additionally, patients with LGI1-directed autoantibodies have frequent focal seizures as a key feature of their disease. LGI1 is compos...

書誌詳細
主要な著者:	Extrémet, J, El Far, O, Ankri, N, Irani, SR, Debanne, D, Russier, M
フォーマット:	Journal article
言語:	English
出版事項:	MDPI 2022

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