Copper-catalysed synthesis of alkylidene 2-pyrrolinone derivatives from the combination of α-keto amides and alkynes
A Cu(I)-catalysed addition and cyclisation sequence has been developed for the synthesis of (E)-alkylidene pyrrolinone derivatives. The reactions incorporate simple α-keto amides and alkynes as substrates, and employ a commercially available Cu(I) catalyst. The process tolerates good variation of bo...
| Auteurs principaux: | , , |
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| Format: | Journal article |
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Royal Society of Chemistry
2018
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| _version_ | 1826257383935967232 |
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| author | Tan, Q Chovatia, P Willis, M |
| author_facet | Tan, Q Chovatia, P Willis, M |
| author_sort | Tan, Q |
| collection | OXFORD |
| description | A Cu(I)-catalysed addition and cyclisation sequence has been developed for the synthesis of (E)-alkylidene pyrrolinone derivatives. The reactions incorporate simple α-keto amides and alkynes as substrates, and employ a commercially available Cu(I) catalyst. The process tolerates good variation of both starting materials, and delivers the desired pyrrolinones in good yields, with high levels of stereocontrol. |
| first_indexed | 2024-03-06T18:17:20Z |
| format | Journal article |
| id | oxford-uuid:050f5760-3f82-428d-82da-d82b5702c912 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T18:17:20Z |
| publishDate | 2018 |
| publisher | Royal Society of Chemistry |
| record_format | dspace |
| spelling | oxford-uuid:050f5760-3f82-428d-82da-d82b5702c9122022-03-26T08:55:07ZCopper-catalysed synthesis of alkylidene 2-pyrrolinone derivatives from the combination of α-keto amides and alkynesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:050f5760-3f82-428d-82da-d82b5702c912Symplectic Elements at OxfordRoyal Society of Chemistry2018Tan, QChovatia, PWillis, MA Cu(I)-catalysed addition and cyclisation sequence has been developed for the synthesis of (E)-alkylidene pyrrolinone derivatives. The reactions incorporate simple α-keto amides and alkynes as substrates, and employ a commercially available Cu(I) catalyst. The process tolerates good variation of both starting materials, and delivers the desired pyrrolinones in good yields, with high levels of stereocontrol. |
| spellingShingle | Tan, Q Chovatia, P Willis, M Copper-catalysed synthesis of alkylidene 2-pyrrolinone derivatives from the combination of α-keto amides and alkynes |
| title | Copper-catalysed synthesis of alkylidene 2-pyrrolinone derivatives from the combination of α-keto amides and alkynes |
| title_full | Copper-catalysed synthesis of alkylidene 2-pyrrolinone derivatives from the combination of α-keto amides and alkynes |
| title_fullStr | Copper-catalysed synthesis of alkylidene 2-pyrrolinone derivatives from the combination of α-keto amides and alkynes |
| title_full_unstemmed | Copper-catalysed synthesis of alkylidene 2-pyrrolinone derivatives from the combination of α-keto amides and alkynes |
| title_short | Copper-catalysed synthesis of alkylidene 2-pyrrolinone derivatives from the combination of α-keto amides and alkynes |
| title_sort | copper catalysed synthesis of alkylidene 2 pyrrolinone derivatives from the combination of α keto amides and alkynes |
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