Environmental and genetic determinants of two vitamin D metabolites in healthy Australian children
<strong>Background:</strong> Vitamin D deficiency has been associated with adverse health outcomes. We examined genetic and environmental determinants of serum 25(OH)D3 and 1,25(OH)2D3 in childhood. <strong>Methods:</strong> The study sample consisted of 322 healthy Australi...
| Glavni autori: | , , , , , , , , , , , , |
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| Format: | Journal article |
| Jezik: | English |
| Izdano: |
De Gruyter
2017
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| _version_ | 1826257393933090816 |
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| author | Bima, A Pezic, A Sun, C Cameron, F Rodda, C van der Mei, I Chiaroni-Clarke, R Dwyer, T Kemp, A Qu, J Carlin, J Ellis, J Ponsonby, A |
| author_facet | Bima, A Pezic, A Sun, C Cameron, F Rodda, C van der Mei, I Chiaroni-Clarke, R Dwyer, T Kemp, A Qu, J Carlin, J Ellis, J Ponsonby, A |
| author_sort | Bima, A |
| collection | OXFORD |
| description | <strong>Background:</strong> Vitamin D deficiency has been associated with adverse health outcomes. We examined genetic and environmental determinants of serum 25(OH)D3 and 1,25(OH)2D3 in childhood. <strong>Methods:</strong> The study sample consisted of 322 healthy Australian children (predominantly Caucasians) who provided a venous blood sample. A parental interview was conducted and skin phototype and anthropometry measures were assessed. Concentrations of 25(OH)D3 and 1,25(OH)2D3 were measured by selective solid-phase extraction-capillary liquid chromatography-tandem mass spectrometry. These concentrations were deseasonalised where relevant to remove the effect of month of sampling. <strong>Results:</strong> Deseasonalised log 25(OH)D3 and 1,25(OH)2D3 concentrations were only moderately correlated (r=0.42, p<0.001). The following predicted both 25(OH)D3 and 1,25(OH)2D3: UVR 6 weeks before the interview, natural skin and eye colour, height and vitamin D allelic metabolism score. The following predicted 25(OH)D3 only: lifetime sunburns and vitamin D allelic synthesis score. Overall, 43.5% and 25.6% of variation in 25(OH)D3 and 1,25(OH)2D3 could be explained. After accounting for 25(OH)D3 concentrations, higher UVR 6 weeks before the interview and vitamin D allelic metabolism score further predicted 1,25(OH)2D3 concentrations. <strong>Conclusions:</strong> Environmental factors and genetic factors contributed to both vitamin D metabolite concentrations. The intriguing finding that the higher ambient UVR contributed to higher 1,25(OH)2D3 after accounting for 25(OH)D3 concentrations requires further evaluation. |
| first_indexed | 2024-03-06T18:17:30Z |
| format | Journal article |
| id | oxford-uuid:051e5bc5-78ed-444f-a85f-10b62ca14f5e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:17:30Z |
| publishDate | 2017 |
| publisher | De Gruyter |
| record_format | dspace |
| spelling | oxford-uuid:051e5bc5-78ed-444f-a85f-10b62ca14f5e2022-03-26T08:55:25ZEnvironmental and genetic determinants of two vitamin D metabolites in healthy Australian childrenJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:051e5bc5-78ed-444f-a85f-10b62ca14f5eEnglishSymplectic Elements at OxfordDe Gruyter2017Bima, APezic, ASun, CCameron, FRodda, Cvan der Mei, IChiaroni-Clarke, RDwyer, TKemp, AQu, JCarlin, JEllis, JPonsonby, A<strong>Background:</strong> Vitamin D deficiency has been associated with adverse health outcomes. We examined genetic and environmental determinants of serum 25(OH)D3 and 1,25(OH)2D3 in childhood. <strong>Methods:</strong> The study sample consisted of 322 healthy Australian children (predominantly Caucasians) who provided a venous blood sample. A parental interview was conducted and skin phototype and anthropometry measures were assessed. Concentrations of 25(OH)D3 and 1,25(OH)2D3 were measured by selective solid-phase extraction-capillary liquid chromatography-tandem mass spectrometry. These concentrations were deseasonalised where relevant to remove the effect of month of sampling. <strong>Results:</strong> Deseasonalised log 25(OH)D3 and 1,25(OH)2D3 concentrations were only moderately correlated (r=0.42, p<0.001). The following predicted both 25(OH)D3 and 1,25(OH)2D3: UVR 6 weeks before the interview, natural skin and eye colour, height and vitamin D allelic metabolism score. The following predicted 25(OH)D3 only: lifetime sunburns and vitamin D allelic synthesis score. Overall, 43.5% and 25.6% of variation in 25(OH)D3 and 1,25(OH)2D3 could be explained. After accounting for 25(OH)D3 concentrations, higher UVR 6 weeks before the interview and vitamin D allelic metabolism score further predicted 1,25(OH)2D3 concentrations. <strong>Conclusions:</strong> Environmental factors and genetic factors contributed to both vitamin D metabolite concentrations. The intriguing finding that the higher ambient UVR contributed to higher 1,25(OH)2D3 after accounting for 25(OH)D3 concentrations requires further evaluation. |
| spellingShingle | Bima, A Pezic, A Sun, C Cameron, F Rodda, C van der Mei, I Chiaroni-Clarke, R Dwyer, T Kemp, A Qu, J Carlin, J Ellis, J Ponsonby, A Environmental and genetic determinants of two vitamin D metabolites in healthy Australian children |
| title | Environmental and genetic determinants of two vitamin D metabolites in healthy Australian children |
| title_full | Environmental and genetic determinants of two vitamin D metabolites in healthy Australian children |
| title_fullStr | Environmental and genetic determinants of two vitamin D metabolites in healthy Australian children |
| title_full_unstemmed | Environmental and genetic determinants of two vitamin D metabolites in healthy Australian children |
| title_short | Environmental and genetic determinants of two vitamin D metabolites in healthy Australian children |
| title_sort | environmental and genetic determinants of two vitamin d metabolites in healthy australian children |
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