Hypovitaminosis D and bone mineral metabolism and bone density in hyperthyroidism.
Little is known about the impact of concomitant vitamin D deficiency on bone mineral density in hyperthyroidism. Therefore, we evaluated bone mineral measures in vitamin D-deficient and sufficient patients with hyperthyroidism. Thirty newly diagnosed consecutive patients with hyperthyroidism were in...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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2010
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| _version_ | 1797051304626880512 |
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| author | Dhanwal, D Kochupillai, N Gupta, N Cooper, C Dennison, E |
| author_facet | Dhanwal, D Kochupillai, N Gupta, N Cooper, C Dennison, E |
| author_sort | Dhanwal, D |
| collection | OXFORD |
| description | Little is known about the impact of concomitant vitamin D deficiency on bone mineral density in hyperthyroidism. Therefore, we evaluated bone mineral measures in vitamin D-deficient and sufficient patients with hyperthyroidism. Thirty newly diagnosed consecutive patients with hyperthyroidism were included. Blood samples were used for measurement of calcium, phosphate, alkaline phosphatase, 25-hydroxy vitamin D [25(OH) D], and parathyroid hormone (PTH). Bone mineral density (BMD) was measured at the hip, spine, and forearm. The patients were divided into vitamin D-deficient (< 25 nmol/L) and vitamin D-sufficient groups (≥ 25 nmol/L). Eight (26.6%) patients had 25(OH) D levels less than 25 nmol/L, with mean ± standard deviation (SD) level of 16.5 ± 3.2 (vitamin D-deficient group 1), and the remainder had a mean ± SD of 46.0 ± 13.5 nmol/L (vitamin D-sufficient group 2). Serum-intact PTH levels were significantly higher in group 1 compared with those in group 2 (31.2 ± 16.3 vs 18.0 ± 13.1 pg/mL; p=0.041). In the vitamin D-deficient group, the mean BMD T-scores were in the osteoporotic range at hip and forearm (-2.65 ± 1.13 and -3.04 ± 1.3) and in the osteopenia range at lumbar spine (-1.83 ± 1.71). However, in vitamin D-sufficient group, the mean BMD T-scores were in the osteopenia range (-1.64 ± 1.0, -1.27 ± 1.6, and -1.60 ± 0.7) at hip, forearm, and lumbar spine, respectively. The mean BMD Z-scores were also significantly lower in vitamin D-deficient group compared with those in vitamin D-sufficient group. Finally, BMD values (gm/cm(2)) at the hip and forearm were significantly lower in the vitamin D-deficient group compared with those in the vitamin D-sufficient group. In conclusion, hyperthyroid patients with concomitant vitamin D deficiency had lower BMD compared with vitamin D-sufficient patients. |
| first_indexed | 2024-03-06T18:17:35Z |
| format | Journal article |
| id | oxford-uuid:05254870-a39d-4fd0-a7fb-80efc3f01ea9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:17:35Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:05254870-a39d-4fd0-a7fb-80efc3f01ea92022-03-26T08:55:36ZHypovitaminosis D and bone mineral metabolism and bone density in hyperthyroidism.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:05254870-a39d-4fd0-a7fb-80efc3f01ea9EnglishSymplectic Elements at Oxford2010Dhanwal, DKochupillai, NGupta, NCooper, CDennison, ELittle is known about the impact of concomitant vitamin D deficiency on bone mineral density in hyperthyroidism. Therefore, we evaluated bone mineral measures in vitamin D-deficient and sufficient patients with hyperthyroidism. Thirty newly diagnosed consecutive patients with hyperthyroidism were included. Blood samples were used for measurement of calcium, phosphate, alkaline phosphatase, 25-hydroxy vitamin D [25(OH) D], and parathyroid hormone (PTH). Bone mineral density (BMD) was measured at the hip, spine, and forearm. The patients were divided into vitamin D-deficient (< 25 nmol/L) and vitamin D-sufficient groups (≥ 25 nmol/L). Eight (26.6%) patients had 25(OH) D levels less than 25 nmol/L, with mean ± standard deviation (SD) level of 16.5 ± 3.2 (vitamin D-deficient group 1), and the remainder had a mean ± SD of 46.0 ± 13.5 nmol/L (vitamin D-sufficient group 2). Serum-intact PTH levels were significantly higher in group 1 compared with those in group 2 (31.2 ± 16.3 vs 18.0 ± 13.1 pg/mL; p=0.041). In the vitamin D-deficient group, the mean BMD T-scores were in the osteoporotic range at hip and forearm (-2.65 ± 1.13 and -3.04 ± 1.3) and in the osteopenia range at lumbar spine (-1.83 ± 1.71). However, in vitamin D-sufficient group, the mean BMD T-scores were in the osteopenia range (-1.64 ± 1.0, -1.27 ± 1.6, and -1.60 ± 0.7) at hip, forearm, and lumbar spine, respectively. The mean BMD Z-scores were also significantly lower in vitamin D-deficient group compared with those in vitamin D-sufficient group. Finally, BMD values (gm/cm(2)) at the hip and forearm were significantly lower in the vitamin D-deficient group compared with those in the vitamin D-sufficient group. In conclusion, hyperthyroid patients with concomitant vitamin D deficiency had lower BMD compared with vitamin D-sufficient patients. |
| spellingShingle | Dhanwal, D Kochupillai, N Gupta, N Cooper, C Dennison, E Hypovitaminosis D and bone mineral metabolism and bone density in hyperthyroidism. |
| title | Hypovitaminosis D and bone mineral metabolism and bone density in hyperthyroidism. |
| title_full | Hypovitaminosis D and bone mineral metabolism and bone density in hyperthyroidism. |
| title_fullStr | Hypovitaminosis D and bone mineral metabolism and bone density in hyperthyroidism. |
| title_full_unstemmed | Hypovitaminosis D and bone mineral metabolism and bone density in hyperthyroidism. |
| title_short | Hypovitaminosis D and bone mineral metabolism and bone density in hyperthyroidism. |
| title_sort | hypovitaminosis d and bone mineral metabolism and bone density in hyperthyroidism |
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