Immunosuppression with monoclonal antibodies. A model to determine the rules for effective serotherapy.
Despite the range of available T cell specific monoclonal antibodies, there are no established rules to predict which might be immunosuppressive. We here describe a series of five rat monoclonal antibodies to a defined T cell antigen (mouse Thy-1) and evaluate their ability to immunosuppress mice. W...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1983
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| _version_ | 1826257439746424832 |
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| author | Cobbold, S Thierfelder, S Waldmann, H |
| author_facet | Cobbold, S Thierfelder, S Waldmann, H |
| author_sort | Cobbold, S |
| collection | OXFORD |
| description | Despite the range of available T cell specific monoclonal antibodies, there are no established rules to predict which might be immunosuppressive. We here describe a series of five rat monoclonal antibodies to a defined T cell antigen (mouse Thy-1) and evaluate their ability to immunosuppress mice. When compared with rabbit anti-lymphocyte globulin, only one of these monoclonal antibodies was able to delay skin allograft rejection and eliminate antibody responses to sheep red blood cells. This antibody was immunosuppressive following intra-peritoneal administration, even though it did not eliminate all of the T cells in vivo. Two factors may be relevant in determining the immunosuppressive properties of this reagent. First, the monoclonal antibody is of the rat IgG2b sub-class, and second, the specificity of the antibody is different to the other monoclonal antibodies in that it reacts with sub-populations of peripheral T cells, thymocytes and non-T cells. In practice, this suggests that to derive suitable monoclonal antibodies for human serotherapy, one should give attention to both the subclass and the fine specificity of the antibody for the target molecule. |
| first_indexed | 2024-03-06T18:18:13Z |
| format | Journal article |
| id | oxford-uuid:055f8abb-dd05-458d-8d6c-21742c43c1ca |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:18:13Z |
| publishDate | 1983 |
| record_format | dspace |
| spelling | oxford-uuid:055f8abb-dd05-458d-8d6c-21742c43c1ca2022-03-26T08:56:46ZImmunosuppression with monoclonal antibodies. A model to determine the rules for effective serotherapy.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:055f8abb-dd05-458d-8d6c-21742c43c1caEnglishSymplectic Elements at Oxford1983Cobbold, SThierfelder, SWaldmann, HDespite the range of available T cell specific monoclonal antibodies, there are no established rules to predict which might be immunosuppressive. We here describe a series of five rat monoclonal antibodies to a defined T cell antigen (mouse Thy-1) and evaluate their ability to immunosuppress mice. When compared with rabbit anti-lymphocyte globulin, only one of these monoclonal antibodies was able to delay skin allograft rejection and eliminate antibody responses to sheep red blood cells. This antibody was immunosuppressive following intra-peritoneal administration, even though it did not eliminate all of the T cells in vivo. Two factors may be relevant in determining the immunosuppressive properties of this reagent. First, the monoclonal antibody is of the rat IgG2b sub-class, and second, the specificity of the antibody is different to the other monoclonal antibodies in that it reacts with sub-populations of peripheral T cells, thymocytes and non-T cells. In practice, this suggests that to derive suitable monoclonal antibodies for human serotherapy, one should give attention to both the subclass and the fine specificity of the antibody for the target molecule. |
| spellingShingle | Cobbold, S Thierfelder, S Waldmann, H Immunosuppression with monoclonal antibodies. A model to determine the rules for effective serotherapy. |
| title | Immunosuppression with monoclonal antibodies. A model to determine the rules for effective serotherapy. |
| title_full | Immunosuppression with monoclonal antibodies. A model to determine the rules for effective serotherapy. |
| title_fullStr | Immunosuppression with monoclonal antibodies. A model to determine the rules for effective serotherapy. |
| title_full_unstemmed | Immunosuppression with monoclonal antibodies. A model to determine the rules for effective serotherapy. |
| title_short | Immunosuppression with monoclonal antibodies. A model to determine the rules for effective serotherapy. |
| title_sort | immunosuppression with monoclonal antibodies a model to determine the rules for effective serotherapy |
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