Diastereoselective conjugate reduction with samarium diiodide: asymmetric synthesis of methyl (2S,3R)-N-acetyl-2-amino-2,3-dideuterio-3-phenylpropionate.
A highly diastereoselective conjugate reduction using SmI2 and D2O has been demonstrated on a homochiral benzylidene diketopiperazine template, giving methyl (2S,3R)-N-acetyl-2-amino-2,3-dideuterio-3-phenylpropionate in 93% de and 90% ee after deprotection, hydrolysis and N-acetylation.
المؤلفون الرئيسيون: | Davies, S, Rodríguez-Solla, H, Tamayo, J, Garner, A, Smith, A |
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التنسيق: | Journal article |
اللغة: | English |
منشور في: |
2004
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مواد مشابهة
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Asymmetric conjugate reductions with samarium diiodide: asymmetric synthesis of (2S,3R)- and (2S,3S)-[2-2H,3-2H]-leucine-(S)-phenylalanine dipeptides and (2S,3R)-[2-(2)H,3-2H]-phenylalanine methyl ester.
حسب: Davies, S, وآخرون
منشور في: (2005) -
A highly diastereoselective [2,3]-sigmatropic N,O rearrangement
حسب: Bull, S, وآخرون
منشور في: (1999) -
Highly diastereoselective lithium enolate aldol reactions of butane-2,3-diacetal desymmetrized glycolic acid and deprotection to enantiopure anti-2,3-dihydroxy esters.
حسب: Dixon, D, وآخرون
منشور في: (2001) -
Highly diastereoselective ketone aldol reactions of butane-2,3-diacetal desymmetrised glycolic acid
حسب: Dixon, D, وآخرون
منشور في: (2002) -
2,3-Di-4-pyridylbutane-2,3-diol
حسب: Niu, Y.Y., وآخرون
منشور في: (2005)