Tethered Aminohydroxylation Reaction and Its Application to Total Synthesis
This review highlights key aspects of the Tethered Aminohydroxylation from its discovery to its current incarnation, which employs N,O-acylated derivatives as reoxidants for osmium. The potential and generality of this reaction has been demonstrated by its application in the synthesis of several nat...
| Main Authors: | , , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado em: |
2012
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| Resumo: | This review highlights key aspects of the Tethered Aminohydroxylation from its discovery to its current incarnation, which employs N,O-acylated derivatives as reoxidants for osmium. The potential and generality of this reaction has been demonstrated by its application in the synthesis of several natural products. A review of the recently developed N-O reoxidants for the tethered aminohydroxylation (TA) reaction is presented. All aspects of the aminohydroxylation reactions that are facilitated are discussed, together with their application in total synthesis. Copyright © 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim. |
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