DNA protein crosslink proteolysis repair: From yeast to premature ageing and cancer in humans

DNA-protein crosslinks (DPCs) are a specific type of DNA lesion consisting of a protein covalently and irreversibly bound to DNA, which arise after exposure to physical and chemical crosslinking agents. DPCs can be bulky and thereby pose a barrier to DNA replication and transcription. The persistenc...

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Autors principals: Fielden, J, Ruggiano, A, Popović, M, Ramadan, K
Format: Journal article
Idioma:English
Publicat: Elsevier 2018