Association of impaired cytochrome P450 2D6 activity genotype and phenotype with therapeutic efficacy of primaquine treatment for latent Plasmodium vivax malaria

Association of impaired cytochrome P450 2D6 activity genotype and phenotype with therapeutic efficacy of primaquine treatment for latent Plasmodium vivax malaria

<strong>Importance</strong> Latent hepatic Plasmodium vivax hypnozoites provoke repeated clinical attacks called relapses. Only primaquine phosphate kills hypnozoites, and its therapeutic activity may depend on naturally polymorphic cytochrome P450 2D6 isotype (CYP2D6) activity. <st...

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Bibliographic Details
Main Authors:	Baird, JK, Louisa, M, Noviyanti, R, Ekawati, L, Elyazar, I, Subekti, D, Chand, K, Gayatri, A, Instiaty, I, Soebianto, S, Crenna-Darusallam, C, Joko, D, Sulistyanto, BP, Meriyenes, D, Wesche, D, Nelwan, EJ, Sutanto, I, Sudoyo, H, Setiabudy, R
Format:	Journal article
Published:	American Medical Association 2018

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