Lack of association of MYO9B genetic variants with coeliac disease in a British cohort.
BACKGROUND AND AIMS: Development of coeliac disease involves an interaction between environmental factors (especially dietary wheat, rye, and barley antigens) and genetic factors (there is strong inherited disease susceptibility). The known human leucocyte antigen (HLA)-DQ2 and -DQ8 association expl...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2006
|
| _version_ | 1797051399253524480 |
|---|---|
| author | Hunt, K Monsuur, A McArdle, W Kumar, P Travis, S Walters, JR Jewell, D Strachan, D Playford, R Wijmenga, C van Heel, D |
| author_facet | Hunt, K Monsuur, A McArdle, W Kumar, P Travis, S Walters, JR Jewell, D Strachan, D Playford, R Wijmenga, C van Heel, D |
| author_sort | Hunt, K |
| collection | OXFORD |
| description | BACKGROUND AND AIMS: Development of coeliac disease involves an interaction between environmental factors (especially dietary wheat, rye, and barley antigens) and genetic factors (there is strong inherited disease susceptibility). The known human leucocyte antigen (HLA)-DQ2 and -DQ8 association explains only a minority of disease heritability. A recent study in the Dutch population suggested that genetic variation in the 3' region of myosin IXB (MYO9B) predisposes to coeliac disease. MYO9B is a Rho family GTPase activating protein involved in epithelial cell cytoskeletal organisation. MYO9B is hypothesised to influence intestinal permeability and hence intestinal antigen presentation. METHODS: Four single nucleotide polymorphisms were chosen to tag all common haplotypes of the MYO9B 3' haplotype block (exons 15-27). We genotyped 375 coeliac disease cases and 1366 controls (371 healthy and 995 population based). All individuals were of White UK Caucasian ethnicity. RESULTS: UK healthy control and population control allele frequencies were similar for all MYO9B variants. Case control analysis showed no significant association of any variant or haplotype with coeliac disease. CONCLUSIONS: Genetic variation in MYO9B does not have a major effect on coeliac disease susceptibility in the UK population. Differences between populations, a weaker effect size than originally described, or possibly a type I error in the Dutch study might explain these findings. |
| first_indexed | 2024-03-06T18:19:00Z |
| format | Journal article |
| id | oxford-uuid:059fb49a-a79f-4ed0-b5d2-feb11f299302 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:19:00Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:059fb49a-a79f-4ed0-b5d2-feb11f2993022022-03-26T08:58:12ZLack of association of MYO9B genetic variants with coeliac disease in a British cohort.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:059fb49a-a79f-4ed0-b5d2-feb11f299302EnglishSymplectic Elements at Oxford2006Hunt, KMonsuur, AMcArdle, WKumar, PTravis, SWalters, JRJewell, DStrachan, DPlayford, RWijmenga, Cvan Heel, DBACKGROUND AND AIMS: Development of coeliac disease involves an interaction between environmental factors (especially dietary wheat, rye, and barley antigens) and genetic factors (there is strong inherited disease susceptibility). The known human leucocyte antigen (HLA)-DQ2 and -DQ8 association explains only a minority of disease heritability. A recent study in the Dutch population suggested that genetic variation in the 3' region of myosin IXB (MYO9B) predisposes to coeliac disease. MYO9B is a Rho family GTPase activating protein involved in epithelial cell cytoskeletal organisation. MYO9B is hypothesised to influence intestinal permeability and hence intestinal antigen presentation. METHODS: Four single nucleotide polymorphisms were chosen to tag all common haplotypes of the MYO9B 3' haplotype block (exons 15-27). We genotyped 375 coeliac disease cases and 1366 controls (371 healthy and 995 population based). All individuals were of White UK Caucasian ethnicity. RESULTS: UK healthy control and population control allele frequencies were similar for all MYO9B variants. Case control analysis showed no significant association of any variant or haplotype with coeliac disease. CONCLUSIONS: Genetic variation in MYO9B does not have a major effect on coeliac disease susceptibility in the UK population. Differences between populations, a weaker effect size than originally described, or possibly a type I error in the Dutch study might explain these findings. |
| spellingShingle | Hunt, K Monsuur, A McArdle, W Kumar, P Travis, S Walters, JR Jewell, D Strachan, D Playford, R Wijmenga, C van Heel, D Lack of association of MYO9B genetic variants with coeliac disease in a British cohort. |
| title | Lack of association of MYO9B genetic variants with coeliac disease in a British cohort. |
| title_full | Lack of association of MYO9B genetic variants with coeliac disease in a British cohort. |
| title_fullStr | Lack of association of MYO9B genetic variants with coeliac disease in a British cohort. |
| title_full_unstemmed | Lack of association of MYO9B genetic variants with coeliac disease in a British cohort. |
| title_short | Lack of association of MYO9B genetic variants with coeliac disease in a British cohort. |
| title_sort | lack of association of myo9b genetic variants with coeliac disease in a british cohort |
| work_keys_str_mv | AT huntk lackofassociationofmyo9bgeneticvariantswithcoeliacdiseaseinabritishcohort AT monsuura lackofassociationofmyo9bgeneticvariantswithcoeliacdiseaseinabritishcohort AT mcardlew lackofassociationofmyo9bgeneticvariantswithcoeliacdiseaseinabritishcohort AT kumarp lackofassociationofmyo9bgeneticvariantswithcoeliacdiseaseinabritishcohort AT traviss lackofassociationofmyo9bgeneticvariantswithcoeliacdiseaseinabritishcohort AT waltersjr lackofassociationofmyo9bgeneticvariantswithcoeliacdiseaseinabritishcohort AT jewelld lackofassociationofmyo9bgeneticvariantswithcoeliacdiseaseinabritishcohort AT strachand lackofassociationofmyo9bgeneticvariantswithcoeliacdiseaseinabritishcohort AT playfordr lackofassociationofmyo9bgeneticvariantswithcoeliacdiseaseinabritishcohort AT wijmengac lackofassociationofmyo9bgeneticvariantswithcoeliacdiseaseinabritishcohort AT vanheeld lackofassociationofmyo9bgeneticvariantswithcoeliacdiseaseinabritishcohort |