Evaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk.

Evaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk.

BACKGROUND: Somatic mutations in phosphoinositide-3-kinase catalytic subunit alpha (PIK3CA) are frequent in breast tumours and have been associated with oestrogen receptor (ER) expression, human epidermal growth factor receptor-2 overexpression, lymph node metastasis and poor survival. The goal of...

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Détails bibliographiques
Auteurs principaux: Stevens, K, Garcia-Closas, M, Fredericksen, Z, Kosel, M, Pankratz, V, Hopper, J, Dite, G, Apicella, C, Southey, M, Schmidt, M, Broeks, A, Van 't Veer, L, Tollenaar, R, Fasching, P, Beckmann, M, Hein, A, Ekici, AB, Johnson, N, Peto, J, dos Santos Silva, I, Gibson, L, Sawyer, E, Tomlinson, I, Kerin, M, Chanock, S
Format: Journal article
Langue:English
Publié: 2011

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