The reality of using primaquine.
BACKGROUND: Primaquine is currently the only medication used for radical cure of Plasmodium vivax infection. Unfortunately, its use is not without risk. Patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency have an increased susceptibility to haemolysis when given primaquine. This poten...
| Những tác giả chính: | , , |
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| Định dạng: | Journal article |
| Ngôn ngữ: | English |
| Được phát hành: |
BioMed Central
2010
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| _version_ | 1826257496533106688 |
|---|---|
| author | Burgoine, K Bancone, G Nosten, F |
| author_facet | Burgoine, K Bancone, G Nosten, F |
| author_sort | Burgoine, K |
| collection | OXFORD |
| description | BACKGROUND: Primaquine is currently the only medication used for radical cure of Plasmodium vivax infection. Unfortunately, its use is not without risk. Patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency have an increased susceptibility to haemolysis when given primaquine. This potentially fatal clinical syndrome can be avoided if patients are tested for G6PD deficiency and adequately informed before being treated. CASE PRESENTATION: A 35-year old male presented to our clinic on the Thai-Burmese border with a history and clinical examination consistent with intravascular haemolysis. The patient had been prescribed primaquine and chloroquine four days earlier for a P. vivax infection. The medication instructions had not been given in a language understood by the patient and he had not been tested for G6PD deficiency. The patient was not only G6PD deficient but misunderstood the instructions and took all his primaquine tablets together. With appropriate treatment the patient recovered and was discharged home a week later. CONCLUSIONS: Whilst primaquine remains the drug of choice to eradicate hypnozoites and control P. vivax transmission, the risks associated with its use must be minimized during its deployment. In areas where P. vivax exists, patients should be tested for G6PD deficiency and adequately informed before administration of primaquine. |
| first_indexed | 2024-03-06T18:19:09Z |
| format | Journal article |
| id | oxford-uuid:05ab2cab-7fa2-43c5-91c9-e36df2123f42 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:19:09Z |
| publishDate | 2010 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | oxford-uuid:05ab2cab-7fa2-43c5-91c9-e36df2123f422022-03-26T08:58:27ZThe reality of using primaquine.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:05ab2cab-7fa2-43c5-91c9-e36df2123f42EnglishSymplectic Elements at OxfordBioMed Central2010Burgoine, KBancone, GNosten, F BACKGROUND: Primaquine is currently the only medication used for radical cure of Plasmodium vivax infection. Unfortunately, its use is not without risk. Patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency have an increased susceptibility to haemolysis when given primaquine. This potentially fatal clinical syndrome can be avoided if patients are tested for G6PD deficiency and adequately informed before being treated. CASE PRESENTATION: A 35-year old male presented to our clinic on the Thai-Burmese border with a history and clinical examination consistent with intravascular haemolysis. The patient had been prescribed primaquine and chloroquine four days earlier for a P. vivax infection. The medication instructions had not been given in a language understood by the patient and he had not been tested for G6PD deficiency. The patient was not only G6PD deficient but misunderstood the instructions and took all his primaquine tablets together. With appropriate treatment the patient recovered and was discharged home a week later. CONCLUSIONS: Whilst primaquine remains the drug of choice to eradicate hypnozoites and control P. vivax transmission, the risks associated with its use must be minimized during its deployment. In areas where P. vivax exists, patients should be tested for G6PD deficiency and adequately informed before administration of primaquine. |
| spellingShingle | Burgoine, K Bancone, G Nosten, F The reality of using primaquine. |
| title | The reality of using primaquine. |
| title_full | The reality of using primaquine. |
| title_fullStr | The reality of using primaquine. |
| title_full_unstemmed | The reality of using primaquine. |
| title_short | The reality of using primaquine. |
| title_sort | reality of using primaquine |
| work_keys_str_mv | AT burgoinek therealityofusingprimaquine AT banconeg therealityofusingprimaquine AT nostenf therealityofusingprimaquine AT burgoinek realityofusingprimaquine AT banconeg realityofusingprimaquine AT nostenf realityofusingprimaquine |