HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice.

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice.

अन्य संस्करण दिखाएं (1)

This study investigated the effects of 2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido) acetic acid (IOX3), a selective small molecule inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylases, on mouse brains subject to transient focal cerebral ischaemia. Male, 8- to 12-week-old C57/B6 mice w...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Chen, R, Ogunshola, O, Yeoh, K, Jani, A, Papadakis, M, Nagel, S, Schofield, C, Buchan, A
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	2014

समान संसाधन

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice
द्वारा: Chen, R, और अन्य
प्रकाशित: (2014)

Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice.
द्वारा: Chen, R, और अन्य
प्रकाशित: (2012)

Neuroprotective Effect of HIF Prolyl Hydroxylase Inhibition in an In Vitro Hypoxia Model
द्वारा: Maria Savyuk, और अन्य
प्रकाशित: (2020-07-01)

Regulation of HIF: prolyl hydroxylases.
द्वारा: Stolze, I, और अन्य
प्रकाशित: (2006)

Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model
द्वारा: Singh, A, और अन्य
प्रकाशित: (2020)

Cerebral blood flow alteration in neuroprotection following cerebral ischaemia.
द्वारा: Sutherland, B, और अन्य
प्रकाशित: (2011)

Cerebral blood flow alteration in neuroprotection following cerebral ischaemia
द्वारा: Sutherland, B, और अन्य
प्रकाशित: (2011)

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
द्वारा: Mole, D, और अन्य
प्रकाशित: (2003)

The use of dioxygen by HIF prolyl hydroxylase (PHD1).
द्वारा: McNeill, L, और अन्य
प्रकाशित: (2002)

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
द्वारा: Schlemminger, I, और अन्य
प्रकाशित: (2003)

Neuroprotection by dimethyloxalylglycine following permanent and transient focal cerebral ischemia in rats.
द्वारा: Nagel, S, और अन्य
प्रकाशित: (2011)

Neuroprotection by dimethyloxalylglycine following permanent and transient focal cerebral ischemia in rats
द्वारा: Nagel, S, और अन्य
प्रकाशित: (2011)

Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents.
द्वारा: Flashman, E, और अन्य
प्रकाशित: (2010)

Therapeutic manipulation of the HIF hydroxylases.
द्वारा: Nagel, S, और अन्य
प्रकाशित: (2010)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
द्वारा: Cockman, M, और अन्य
प्रकाशित: (2019)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
द्वारा: Matthew E Cockman, और अन्य
प्रकाशित: (2019-09-01)

Determination and comparison of specific activity of the HIF-prolyl hydroxylases.
द्वारा: Tuckerman, JR, और अन्य
प्रकाशित: (2004)

Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
द्वारा: Chan, M, और अन्य
प्रकाशित: (2016)

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
द्वारा: Chowdhury, R, और अन्य
प्रकाशित: (2013)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
द्वारा: Chowdhury, R, और अन्य
प्रकाशित: (2016)

Discovery of neuroprotective agents that inhibit human prolyl hydroxylase PHD2
द्वारा: Richardson, NL, और अन्य
प्रकाशित: (2021)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
द्वारा: Rasheduzzaman Chowdhury, और अन्य
प्रकाशित: (2016-08-01)

Molecular and Cellular Mechanisms of HIF Prolyl Hydroxylase inhibitors in Clinical Trials
द्वारा: Yeh, TL, और अन्य
प्रकाशित: (2017)

Inhibition of HIF-prolyl hydroxylases improves healing of intestinal anastomoses
द्वारा: Moritz J. Strowitzki, और अन्य
प्रकाशित: (2021-04-01)

Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion.
द्वारा: Yeoh, K, और अन्य
प्रकाशित: (2013)

Tissue expression and functional insights into HIF prolyl hydroxylase domain enzymes
द्वारा: Wijeyekoon, JB
प्रकाशित: (2013)

HIF Prolyl Hydroxylase Inhibitors for COVID-19 Treatment: Pros and Cons
द्वारा: Andrey A. Poloznikov, और अन्य
प्रकाशित: (2021-01-01)

USE OF PROLYL HYDROXYLASE INHIBITORS TO INDUCE HIF-RELATED METABOLIC CHANGES AND INCREASE C-KIT EXPRESSION IN CARDIOSPHERE-DERIVED CELLS
द्वारा: Tan, S, और अन्य
प्रकाशित: (2011)

Inhibition of a viral prolyl hydroxylase
द्वारा: Langley, G, और अन्य
प्रकाशित: (2019)

Mutation Analysis of HIF-prolyl hydroxylases (PHD/EGLN) in Inherited Phaeochromocytoma and Renal Cell Carcinoma
द्वारा: Astuti, D, और अन्य
प्रकाशित: (2010)

Suppression of the inflammatory response by diphenyleneiodonium after transient focal cerebral ischemia.
द्वारा: Nagel, S, और अन्य
प्रकाशित: (2012)

Relative Contribution of Prolyl Hydroxylase-Dependent and -Independent Degradation of HIF-1alpha by Proteasomal Pathways in Cerebral Ischemia
द्वारा: Yomna Badawi, और अन्य
प्रकाशित: (2017-05-01)

A fluorescent benzo[g]isoquinoline-based HIF prolyl hydroxylase inhibitor for cellular imaging
द्वारा: Mayer, M, और अन्य
प्रकाशित: (2018)

Structure–activity relationship and crystallographic studies on 4-hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors
द्वारा: Holt-Martyn, JP, और अन्य
प्रकाशित: (2019)

Structural, biochemical and inhibition studies on hypoxia-inducible factor (HIF) prolyl hydroxylases
द्वारा: Lippl, K
प्रकाशित: (2018)

HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels.
द्वारा: Masson, N, और अन्य
प्रकाशित: (2003)

Impact of HIF prolyl hydroxylase inhibitors in heart failure patients with renal anemia
द्वारा: Takahiro Kambara, और अन्य
प्रकाशित: (2024-03-01)

HIF-α Prolyl Hydroxylase Inhibitors and Their Implications for Biomedicine: A Comprehensive Review
द्वारा: Kiichi Hirota
प्रकाशित: (2021-04-01)

The HIF-prolyl hydroxylases have distinct and nonredundant roles in colitis-associated cancer
द्वारा: Kilian B. Kennel, और अन्य
प्रकाशित: (2022-11-01)

Network activity in primary hippocampal cultures upon HIF-prolyl hydroxylase inhibition
द्वारा: Savyuk, Maria Olegovna, और अन्य
प्रकाशित: (2021-05-01)