HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice.

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice.

Veure altres versions (1)

This study investigated the effects of 2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido) acetic acid (IOX3), a selective small molecule inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylases, on mouse brains subject to transient focal cerebral ischaemia. Male, 8- to 12-week-old C57/B6 mice w...

Descripció completa

Dades bibliogràfiques
Autors principals:	Chen, R, Ogunshola, O, Yeoh, K, Jani, A, Papadakis, M, Nagel, S, Schofield, C, Buchan, A
Format:	Journal article
Idioma:	English
Publicat:	2014

Ítems similars

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice
per: Chen, R, et al.
Publicat: (2014)

Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice.
per: Chen, R, et al.
Publicat: (2012)

Neuroprotective Effect of HIF Prolyl Hydroxylase Inhibition in an In Vitro Hypoxia Model
per: Maria Savyuk, et al.
Publicat: (2020-07-01)

Regulation of HIF: prolyl hydroxylases.
per: Stolze, I, et al.
Publicat: (2006)

Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model
per: Singh, A, et al.
Publicat: (2020)

Cerebral blood flow alteration in neuroprotection following cerebral ischaemia.
per: Sutherland, B, et al.
Publicat: (2011)

Cerebral blood flow alteration in neuroprotection following cerebral ischaemia
per: Sutherland, B, et al.
Publicat: (2011)

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
per: Mole, D, et al.
Publicat: (2003)

The use of dioxygen by HIF prolyl hydroxylase (PHD1).
per: McNeill, L, et al.
Publicat: (2002)

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
per: Schlemminger, I, et al.
Publicat: (2003)

Neuroprotection by dimethyloxalylglycine following permanent and transient focal cerebral ischemia in rats.
per: Nagel, S, et al.
Publicat: (2011)

Neuroprotection by dimethyloxalylglycine following permanent and transient focal cerebral ischemia in rats
per: Nagel, S, et al.
Publicat: (2011)

Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents.
per: Flashman, E, et al.
Publicat: (2010)

Therapeutic manipulation of the HIF hydroxylases.
per: Nagel, S, et al.
Publicat: (2010)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
per: Cockman, M, et al.
Publicat: (2019)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
per: Matthew E Cockman, et al.
Publicat: (2019-09-01)

Determination and comparison of specific activity of the HIF-prolyl hydroxylases.
per: Tuckerman, JR, et al.
Publicat: (2004)

Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
per: Chan, M, et al.
Publicat: (2016)

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
per: Chowdhury, R, et al.
Publicat: (2013)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
per: Chowdhury, R, et al.
Publicat: (2016)

Discovery of neuroprotective agents that inhibit human prolyl hydroxylase PHD2
per: Richardson, NL, et al.
Publicat: (2021)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
per: Rasheduzzaman Chowdhury, et al.
Publicat: (2016-08-01)

Molecular and Cellular Mechanisms of HIF Prolyl Hydroxylase inhibitors in Clinical Trials
per: Yeh, TL, et al.
Publicat: (2017)

Inhibition of HIF-prolyl hydroxylases improves healing of intestinal anastomoses
per: Moritz J. Strowitzki, et al.
Publicat: (2021-04-01)

Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion.
per: Yeoh, K, et al.
Publicat: (2013)

Tissue expression and functional insights into HIF prolyl hydroxylase domain enzymes
per: Wijeyekoon, JB
Publicat: (2013)

HIF Prolyl Hydroxylase Inhibitors for COVID-19 Treatment: Pros and Cons
per: Andrey A. Poloznikov, et al.
Publicat: (2021-01-01)

USE OF PROLYL HYDROXYLASE INHIBITORS TO INDUCE HIF-RELATED METABOLIC CHANGES AND INCREASE C-KIT EXPRESSION IN CARDIOSPHERE-DERIVED CELLS
per: Tan, S, et al.
Publicat: (2011)

Inhibition of a viral prolyl hydroxylase
per: Langley, G, et al.
Publicat: (2019)

Mutation Analysis of HIF-prolyl hydroxylases (PHD/EGLN) in Inherited Phaeochromocytoma and Renal Cell Carcinoma
per: Astuti, D, et al.
Publicat: (2010)

Suppression of the inflammatory response by diphenyleneiodonium after transient focal cerebral ischemia.
per: Nagel, S, et al.
Publicat: (2012)

Relative Contribution of Prolyl Hydroxylase-Dependent and -Independent Degradation of HIF-1alpha by Proteasomal Pathways in Cerebral Ischemia
per: Yomna Badawi, et al.
Publicat: (2017-05-01)

A fluorescent benzo[g]isoquinoline-based HIF prolyl hydroxylase inhibitor for cellular imaging
per: Mayer, M, et al.
Publicat: (2018)

Structure–activity relationship and crystallographic studies on 4-hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors
per: Holt-Martyn, JP, et al.
Publicat: (2019)

Structural, biochemical and inhibition studies on hypoxia-inducible factor (HIF) prolyl hydroxylases
per: Lippl, K
Publicat: (2018)

HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels.
per: Masson, N, et al.
Publicat: (2003)

Impact of HIF prolyl hydroxylase inhibitors in heart failure patients with renal anemia
per: Takahiro Kambara, et al.
Publicat: (2024-03-01)

HIF-α Prolyl Hydroxylase Inhibitors and Their Implications for Biomedicine: A Comprehensive Review
per: Kiichi Hirota
Publicat: (2021-04-01)

The HIF-prolyl hydroxylases have distinct and nonredundant roles in colitis-associated cancer
per: Kilian B. Kennel, et al.
Publicat: (2022-11-01)

Network activity in primary hippocampal cultures upon HIF-prolyl hydroxylase inhibition
per: Savyuk, Maria Olegovna, et al.
Publicat: (2021-05-01)