The association between type 2 diabetes mellitus, hip fracture, and post-hip fracture mortality: a multi-state cohort analysis
<p><strong>Summary</strong> Type 2 diabetes mellitus (T2DM) is associated with an excess risk of fractures and overall mortality. This study compared hip fracture and post-hip fracture mortality in T2DM and non-diabetic subjects. The salient findings are that subjects in T2DM are a...
| Autors principals: | , , , , , , , |
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| Format: | Journal article |
| Idioma: | English |
| Publicat: |
Springer London
2019
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| _version_ | 1826257525138259968 |
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| author | Tebé, C Martínez-Laguna, D Carbonell-Abella, C Reyes, C Moreno, V Diez-Perez, A Collins, G Prieto Alhambra, D |
| author_facet | Tebé, C Martínez-Laguna, D Carbonell-Abella, C Reyes, C Moreno, V Diez-Perez, A Collins, G Prieto Alhambra, D |
| author_sort | Tebé, C |
| collection | OXFORD |
| description | <p><strong>Summary</strong> Type 2 diabetes mellitus (T2DM) is associated with an excess risk of fractures and overall mortality. This study compared hip fracture and post-hip fracture mortality in T2DM and non-diabetic subjects. The salient findings are that subjects in T2DM are at higher risk of dying after suffering a hip fracture.</p> <p><strong>Introduction</strong> Previous research suggests that individuals with T2DM are at an excess risk of both fractures and overall mortality, but their combined effect is unknown. Using multi-state cohort analyses, we estimate the association between T2DM and the transition to hip fracture, post-hip fracture mortality, and hip fracture–free all-cause death.</p> <p><strong>Methods</strong> Population-based cohort from Catalonia, Spain, including all individuals aged 65 to 80 years with a recorded diagnosis of T2DM on 1 January 2006; and non-T2DM matched (up to 2:1) by year of birth, gender, and primary care practice.</p> <p><strong>Results</strong> A total of 44,802 T2DM and 81,233 matched controls (53% women, mean age 72 years old) were followed for a median of 8 years: 23,818 died without fracturing and 3317 broke a hip, of whom 838 subsequently died. Adjusted HRs for hip fracture–free mortality were 1.32 (95% CI 1.28 to 1.37) for men and 1.72 (95% CI 1.65 to 1.79) for women. HRs for hip fracture were 1.24 (95% CI 1.08 to 1.43) and 1.48 (95% CI 1.36 to 1.60), whilst HRs for post-hip fracture mortality were 1.28 (95% CI 1.02 to 1.60) and 1.57 (95% CI 1.31 to 1.88) in men and women, respectively.</p> <p><strong>Conclusion</strong> T2DM individuals are at increased risk of hip fracture, post-hip fracture mortality, and hip fracture–free death. After adjustment, T2DM men were at a 28% higher risk of dying after suffering a hip fracture and women had 57% excess risk of post-hip fracture mortality.</p> |
| first_indexed | 2024-03-06T18:19:36Z |
| format | Journal article |
| id | oxford-uuid:05d0ec3c-aef6-4018-bccc-db5ac86282e8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:19:36Z |
| publishDate | 2019 |
| publisher | Springer London |
| record_format | dspace |
| spelling | oxford-uuid:05d0ec3c-aef6-4018-bccc-db5ac86282e82022-03-26T08:59:12ZThe association between type 2 diabetes mellitus, hip fracture, and post-hip fracture mortality: a multi-state cohort analysisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:05d0ec3c-aef6-4018-bccc-db5ac86282e8EnglishSymplectic Elements at OxfordSpringer London2019Tebé, CMartínez-Laguna, DCarbonell-Abella, CReyes, CMoreno, VDiez-Perez, ACollins, GPrieto Alhambra, D<p><strong>Summary</strong> Type 2 diabetes mellitus (T2DM) is associated with an excess risk of fractures and overall mortality. This study compared hip fracture and post-hip fracture mortality in T2DM and non-diabetic subjects. The salient findings are that subjects in T2DM are at higher risk of dying after suffering a hip fracture.</p> <p><strong>Introduction</strong> Previous research suggests that individuals with T2DM are at an excess risk of both fractures and overall mortality, but their combined effect is unknown. Using multi-state cohort analyses, we estimate the association between T2DM and the transition to hip fracture, post-hip fracture mortality, and hip fracture–free all-cause death.</p> <p><strong>Methods</strong> Population-based cohort from Catalonia, Spain, including all individuals aged 65 to 80 years with a recorded diagnosis of T2DM on 1 January 2006; and non-T2DM matched (up to 2:1) by year of birth, gender, and primary care practice.</p> <p><strong>Results</strong> A total of 44,802 T2DM and 81,233 matched controls (53% women, mean age 72 years old) were followed for a median of 8 years: 23,818 died without fracturing and 3317 broke a hip, of whom 838 subsequently died. Adjusted HRs for hip fracture–free mortality were 1.32 (95% CI 1.28 to 1.37) for men and 1.72 (95% CI 1.65 to 1.79) for women. HRs for hip fracture were 1.24 (95% CI 1.08 to 1.43) and 1.48 (95% CI 1.36 to 1.60), whilst HRs for post-hip fracture mortality were 1.28 (95% CI 1.02 to 1.60) and 1.57 (95% CI 1.31 to 1.88) in men and women, respectively.</p> <p><strong>Conclusion</strong> T2DM individuals are at increased risk of hip fracture, post-hip fracture mortality, and hip fracture–free death. After adjustment, T2DM men were at a 28% higher risk of dying after suffering a hip fracture and women had 57% excess risk of post-hip fracture mortality.</p> |
| spellingShingle | Tebé, C Martínez-Laguna, D Carbonell-Abella, C Reyes, C Moreno, V Diez-Perez, A Collins, G Prieto Alhambra, D The association between type 2 diabetes mellitus, hip fracture, and post-hip fracture mortality: a multi-state cohort analysis |
| title | The association between type 2 diabetes mellitus, hip fracture, and post-hip fracture mortality: a multi-state cohort analysis |
| title_full | The association between type 2 diabetes mellitus, hip fracture, and post-hip fracture mortality: a multi-state cohort analysis |
| title_fullStr | The association between type 2 diabetes mellitus, hip fracture, and post-hip fracture mortality: a multi-state cohort analysis |
| title_full_unstemmed | The association between type 2 diabetes mellitus, hip fracture, and post-hip fracture mortality: a multi-state cohort analysis |
| title_short | The association between type 2 diabetes mellitus, hip fracture, and post-hip fracture mortality: a multi-state cohort analysis |
| title_sort | association between type 2 diabetes mellitus hip fracture and post hip fracture mortality a multi state cohort analysis |
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