DNA sequence variation in ACVR1C encoding the activin receptor-like kinase 7 influences body fat distribution and protects against type 2 diabetes

DNA sequence variation in ACVR1C encoding the activin receptor-like kinase 7 influences body fat distribution and protects against type 2 diabetes

A genetic predisposition to higher waist-to-hip ratio adjusted for BMI (WHRadjBMI), a measure of body fat distribution, associates with increased risk for type 2 diabetes. We conducted an exome-wide association study of coding variation in UK Biobank (405,569 individuals) to identify variants that l...

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Những tác giả chính: Emdin, C, Khera, A, Aragam, K, Haas, M, Chaffin, M, Klarin, D, Natarajan, P, Bick, A, Zekavat, S, Nomura, A, Ardissino, D, Wilson, J, Schunkert, H, McPherson, R, Watkins, H, Elosua, R, Bown, M, Samani, N, Baber, U, Erdmann, J, Gupta, N, Danesh, J, Saleheen, D, Gabriel, S, Kathiresan, S
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: American Diabetes Association 2018

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