Offsetting virulence and antibiotic resistance costs by MRSA.
The prevalence of diverse MRSA (methicillin-resistant Staphylococcus aureus) types in both hospital and community settings is a major health problem worldwide. Here we compare hospital-acquired MRSAs with large type II SCCmec elements with those prevalent in both hospital and community settings with...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2010
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| _version_ | 1797051461509578752 |
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| author | Collins, J Rudkin, J Recker, M Pozzi, C O'Gara, J Massey, R |
| author_facet | Collins, J Rudkin, J Recker, M Pozzi, C O'Gara, J Massey, R |
| author_sort | Collins, J |
| collection | OXFORD |
| description | The prevalence of diverse MRSA (methicillin-resistant Staphylococcus aureus) types in both hospital and community settings is a major health problem worldwide. Here we compare hospital-acquired MRSAs with large type II SCCmec elements with those prevalent in both hospital and community settings with smaller type IV SCCmec elements. We find that the type II but not the type IV SCCmec element causes the bacteria to reduce their levels of costly toxin expression. We compare the relative growth rates of these MRSA types and show that the type II SCCmec carrying MRSAs are more affected than those carrying type IV elements and from this we hypothesize that offsetting the costs associated with antibiotic resistance and toxin expression is why the type II are confined to hospital environments where antibiotic use, the prevalence of immunocompromised individuals and vector-mediated transmission is high. In contrast, those MRSAs that are also successful in the community can maintain their high levels of toxin expression due to a lower fitness burden associated with the smaller SCCmec element. |
| first_indexed | 2024-03-06T18:19:51Z |
| format | Journal article |
| id | oxford-uuid:05e6c106-090e-40db-93c4-7464f9f233e0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:19:51Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:05e6c106-090e-40db-93c4-7464f9f233e02022-03-26T08:59:39ZOffsetting virulence and antibiotic resistance costs by MRSA.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:05e6c106-090e-40db-93c4-7464f9f233e0EnglishSymplectic Elements at Oxford2010Collins, JRudkin, JRecker, MPozzi, CO'Gara, JMassey, RThe prevalence of diverse MRSA (methicillin-resistant Staphylococcus aureus) types in both hospital and community settings is a major health problem worldwide. Here we compare hospital-acquired MRSAs with large type II SCCmec elements with those prevalent in both hospital and community settings with smaller type IV SCCmec elements. We find that the type II but not the type IV SCCmec element causes the bacteria to reduce their levels of costly toxin expression. We compare the relative growth rates of these MRSA types and show that the type II SCCmec carrying MRSAs are more affected than those carrying type IV elements and from this we hypothesize that offsetting the costs associated with antibiotic resistance and toxin expression is why the type II are confined to hospital environments where antibiotic use, the prevalence of immunocompromised individuals and vector-mediated transmission is high. In contrast, those MRSAs that are also successful in the community can maintain their high levels of toxin expression due to a lower fitness burden associated with the smaller SCCmec element. |
| spellingShingle | Collins, J Rudkin, J Recker, M Pozzi, C O'Gara, J Massey, R Offsetting virulence and antibiotic resistance costs by MRSA. |
| title | Offsetting virulence and antibiotic resistance costs by MRSA. |
| title_full | Offsetting virulence and antibiotic resistance costs by MRSA. |
| title_fullStr | Offsetting virulence and antibiotic resistance costs by MRSA. |
| title_full_unstemmed | Offsetting virulence and antibiotic resistance costs by MRSA. |
| title_short | Offsetting virulence and antibiotic resistance costs by MRSA. |
| title_sort | offsetting virulence and antibiotic resistance costs by mrsa |
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