Dose-dependent Nodal/Smad signals pattern the early mouse embryo
Nodal signals in the early post-implantation stage embryo are essential to establish initial proximal-distal (P-D) polarity and generate the final anterior-posterior (A-P) body axis. Nodal signaling in the epiblast results in the phosphorylation of Smad2 in the overlying visceral endoderm necessary...
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| Format: | Journal article |
| Language: | English |
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Elsevier
2014
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| _version_ | 1797051503662333952 |
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| author | Robertson, E |
| author_facet | Robertson, E |
| author_sort | Robertson, E |
| collection | OXFORD |
| description | Nodal signals in the early post-implantation stage embryo are essential to establish initial proximal-distal (P-D) polarity and generate the final anterior-posterior (A-P) body axis. Nodal signaling in the epiblast results in the phosphorylation of Smad2 in the overlying visceral endoderm necessary to induce the AVE, in part via Smad2-dependent activation of the T-box gene Eomesodermin. Slightly later following mesoderm induction a continuum of dose-dependent Nodal signaling during the process of gastrulation underlies specification of mesodermal and definitive endoderm progenitors. Dynamic Nodal expression during the critical 72 h time window immediately following implantation, accomplished by a series of feed-back and feed-forward mechanisms serves to provide key positional cues required for establishment of the body plan and controls cell fate decisions in the early mammalian embryo. © 2014. |
| first_indexed | 2024-03-06T18:20:24Z |
| format | Journal article |
| id | oxford-uuid:0613d4f2-202b-45f2-8e60-f924b54f0e89 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:20:24Z |
| publishDate | 2014 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:0613d4f2-202b-45f2-8e60-f924b54f0e892022-03-26T09:00:40ZDose-dependent Nodal/Smad signals pattern the early mouse embryoJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0613d4f2-202b-45f2-8e60-f924b54f0e89EnglishSymplectic Elements at OxfordElsevier2014Robertson, ENodal signals in the early post-implantation stage embryo are essential to establish initial proximal-distal (P-D) polarity and generate the final anterior-posterior (A-P) body axis. Nodal signaling in the epiblast results in the phosphorylation of Smad2 in the overlying visceral endoderm necessary to induce the AVE, in part via Smad2-dependent activation of the T-box gene Eomesodermin. Slightly later following mesoderm induction a continuum of dose-dependent Nodal signaling during the process of gastrulation underlies specification of mesodermal and definitive endoderm progenitors. Dynamic Nodal expression during the critical 72 h time window immediately following implantation, accomplished by a series of feed-back and feed-forward mechanisms serves to provide key positional cues required for establishment of the body plan and controls cell fate decisions in the early mammalian embryo. © 2014. |
| spellingShingle | Robertson, E Dose-dependent Nodal/Smad signals pattern the early mouse embryo |
| title | Dose-dependent Nodal/Smad signals pattern the early mouse embryo |
| title_full | Dose-dependent Nodal/Smad signals pattern the early mouse embryo |
| title_fullStr | Dose-dependent Nodal/Smad signals pattern the early mouse embryo |
| title_full_unstemmed | Dose-dependent Nodal/Smad signals pattern the early mouse embryo |
| title_short | Dose-dependent Nodal/Smad signals pattern the early mouse embryo |
| title_sort | dose dependent nodal smad signals pattern the early mouse embryo |
| work_keys_str_mv | AT robertsone dosedependentnodalsmadsignalspatterntheearlymouseembryo |