Effects of folic acid supplementation on overall and site-specific cancer incidence during the randomised trials: meta-analyses of data on 50,000 individuals.

Some countries fortify flour with folic acid to prevent neural tube defects but others do not, partly because of concerns about possible cancer risks. We aimed to assess any effects on site-specific cancer rates in the randomised trials of folic acid supplementation, at doses higher than those from...

Full description

Bibliographic Details
Main Authors: Vollset, SE, Clarke, R, Lewington, S, Ebbing, M, Halsey, J, Lonn, E, Armitage, J, Manson, J, Hankey, G, Spence, J, Galan, P, Bønaa, K, Jamison, R, Gaziano, J, Guarino, P, Baron, J, Logan, R, Giovannucci, E, den Heijer, M, Ueland, P, Bennett, D, Collins, R, Peto, R, B-Vitamin Treatment Trialists' Collaboration
Format: Journal article
Language:English
Published: 2013
Description
Summary:Some countries fortify flour with folic acid to prevent neural tube defects but others do not, partly because of concerns about possible cancer risks. We aimed to assess any effects on site-specific cancer rates in the randomised trials of folic acid supplementation, at doses higher than those from fortification.