Increased InsP3Rs in the junctional sarcoplasmic reticulum augment Ca2+ transients and arrhythmias associated with cardiac hypertrophy.
Cardiac hypertrophy is a growth response of the heart to increased hemodynamic demand or damage. Accompanying this heart enlargement is a remodeling of Ca(2+) signaling. Due to its fundamental role in controlling cardiomyocyte contraction during every heartbeat, modifications in Ca(2+) fluxes signif...
Main Authors: | Harzheim, D, Movassagh, M, Foo, R, Ritter, O, Tashfeen, A, Conway, S, Bootman, MD, Roderick, H |
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Format: | Journal article |
Language: | English |
Published: |
2009
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