Repeat protein architectures predicted by a continuum representation of fold space.
It is an open question whether nature has utilized all possible protein folds. For a simple protein architecture, the helical repeats, we report a method to address this question based on a mapping between the set of repetitive curves and a space of parameters specifying the curve. The exploration o...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2006
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| _version_ | 1797051569513955328 |
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| author | Hausrath, A Goriely, A |
| author_facet | Hausrath, A Goriely, A |
| author_sort | Hausrath, A |
| collection | OXFORD |
| description | It is an open question whether nature has utilized all possible protein folds. For a simple protein architecture, the helical repeats, we report a method to address this question based on a mapping between the set of repetitive curves and a space of parameters specifying the curve. The exploration of the parameter space for a particular architecture enables a systematic exploration of the fold space for that protein architecture. In a planar subspace of the parameter space of helical repeats we have identified points corresponding to both naturally occurring folds and potential folds not observed so far. |
| first_indexed | 2024-03-06T18:21:22Z |
| format | Journal article |
| id | oxford-uuid:066a6eac-0016-4802-820e-603e714ae282 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:21:22Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:066a6eac-0016-4802-820e-603e714ae2822022-03-26T09:02:18ZRepeat protein architectures predicted by a continuum representation of fold space.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:066a6eac-0016-4802-820e-603e714ae282EnglishSymplectic Elements at Oxford2006Hausrath, AGoriely, AIt is an open question whether nature has utilized all possible protein folds. For a simple protein architecture, the helical repeats, we report a method to address this question based on a mapping between the set of repetitive curves and a space of parameters specifying the curve. The exploration of the parameter space for a particular architecture enables a systematic exploration of the fold space for that protein architecture. In a planar subspace of the parameter space of helical repeats we have identified points corresponding to both naturally occurring folds and potential folds not observed so far. |
| spellingShingle | Hausrath, A Goriely, A Repeat protein architectures predicted by a continuum representation of fold space. |
| title | Repeat protein architectures predicted by a continuum representation of fold space. |
| title_full | Repeat protein architectures predicted by a continuum representation of fold space. |
| title_fullStr | Repeat protein architectures predicted by a continuum representation of fold space. |
| title_full_unstemmed | Repeat protein architectures predicted by a continuum representation of fold space. |
| title_short | Repeat protein architectures predicted by a continuum representation of fold space. |
| title_sort | repeat protein architectures predicted by a continuum representation of fold space |
| work_keys_str_mv | AT hausratha repeatproteinarchitecturespredictedbyacontinuumrepresentationoffoldspace AT gorielya repeatproteinarchitecturespredictedbyacontinuumrepresentationoffoldspace |