RUNX1 Is a Key Target in t(4;11) Leukemias that Contributes to Gene Activation through an AF4-MLL Complex Interaction

RUNX1 Is a Key Target in t(4;11) Leukemias that Contributes to Gene Activation through an AF4-MLL Complex Interaction

Show other versions (1)

The Mixed Lineage Leukemia (MLL) protein is an important epigenetic regulator required for the maintenance of gene activation during development. MLL chromosomal translocations produce novel fusion proteins that cause aggressive leukemias in humans. Individual MLL fusion proteins have distinct leuke...

書目詳細資料
Main Authors:	Wilkinson, A, Ballabio, E, Geng, H, North, P, Tapia, M, Kerry, J, Biswas, D, Roeder, R, Allis, C, Melnick, A, de Bruijn, M, Milne, T
格式:	Journal article
出版:	2013

相似書籍

RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction.
由: Wilkinson, A, et al.
出版: (2013)

PAF1 and FACT cooperate with MLL-AF4 to drive enhancer activity in leukemia
由: Milne, T, et al.
出版: (2022)

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia.
由: Kerry, J, et al.
出版: (2017)

MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia
由: Crump, NT, et al.
出版: (2023)

MLL-AF4 binds directly to a BCL-2 specific enhancer and modulates H3K27 acetylation.
由: Godfrey, L, et al.
出版: (2016)

The function of PRC2 in MLL-AF4 acute lymphoid leukaemia
由: Tapia, M
出版: (2015)

The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia
由: Numata, A, et al.
出版: (2018)

Next generation sequencing techniques reveal molecular mechanisms of MYB regulation and function in MLL-AF9 Leukemia
由: Lau, I, et al.
出版: (2017)

Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes.
由: Biswas, D, et al.
出版: (2011)

The role of DOT1L in MLL-AF4 leukaemia
由: Godfrey, L
出版: (2018)

Machine learning methods for next generation sequencing data: applications to MLL-AF4 leukemia and demographic inference
由: Cole, CB
出版: (2021)

Regulation of MLL1 H3K4 methyltransferase activity by its core components.
由: Dou, Y, et al.
出版: (2006)

Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis.
由: Ballabio, E, et al.
出版: (2012)

Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.
由: Dou, Y, et al.
出版: (2005)

The role of MYB in MLL-AF9 leukaemia
由: Lau, IJ
出版: (2019)

A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program
由: Rice, S, et al.
出版: (2021)

A conditional model of MLL-AF4 B-cell tumourigenesis using invertor technology.
由: Metzler, M, et al.
出版: (2006)

Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis.
由: Milne, T, et al.
出版: (2010)

Multiple Interactions Recruit MLL1 and MLL1 Fusion Proteins to the HOXA9 Locus in Leukemogenesis
由: Milne, T, et al.
出版: (2010)

Mouse Af9 is a controller of embryo patterning, like Mll, whose human homologue fuses with Af9 after chromosomal translocation in leukemia.
由: Collins, E, et al.
出版: (2002)

A novel mutation in the miR-128b gene reduces miRNA processing and leads to glucocorticoid resistance of MLL-AF4 Acute Lymphocytic Leukemia cells
由: Kotani, Ai, et al.
出版: (2012)

H3K79me2/3 controls enhancer–promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells
由: Godfrey, L, et al.
出版: (2020)

Fusi gena Tel-Aml1, BCR-ABL, E2A-PBX1 dan MLL-Af4 sebagai faktor prognosis leukemia limfoblastik akut
由: , MULATSIH, Sri, et al.
出版: (2010)

MLL associates specifically with a subset of transcriptionally active target genes.
由: Milne, T, et al.
出版: (2005)

Extending the repertoire of the mixed-lineage leukemia gene MLL in leukemogenesis.
由: Daser, A, et al.
出版: (2004)

MLL targets SET domain methyltransferase activity to Hox gene promoters.
由: Milne, T, et al.
出版: (2002)

MLL-rearranged acute lymphoblastic leukemias activate BCL-2 through H3K79 methylation and are sensitive to the BCL-2-specific antagonist ABT-199
由: Benito, J, et al.
出版: (2015)

Developmentally regulated molecular programmes in human fetal haematopoietic cells cooperate with MLL-AF4 to drive infant acute lymphoblastic leukaemia
由: Rice, S
出版: (2021)

Effects of newcastle disease virus strains AF2240 and V4-UPM on cytolysis and apoptosis of leukemia cell lines
由: Alabsi, A.M., et al.
出版: (2010)

Genetic screening to investigate treatment resistance in MLL-rearranged leukemia
由: Jamilly, M
出版: (2019)

Integrative Genome Wide DNA Methylation and Gene Expression Analysis Reveals Biological and Clinical Insights In Adult Acute Lymphoblastic Leukemia
由: Geng, H, et al.
出版: (2010)

Integrative Genome-Wide DNA Methylation and Gene Expression Analysis Reveals Biological and Clinical Insights In Adult Acute Lymphoblastic Leukemia
由: Geng, H, et al.
出版: (2010)

Integrative Genome Wide DNA Methylation and Gene Expression Analysis Reveals Biological and Clinical Insights In Adult Acute Lymphoblastic Leukemia
由: Geng, H, et al.
出版: (2010)

Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression.
由: Wang, Z, et al.
出版: (2010)

Inter-chromosomal recombination of Mll and Af9 genes mediated by cre-loxP in mouse development.
由: Collins, E, et al.
出版: (2000)

TET1 plays an essential oncogenic role in MLL-rearranged leukemia
由: Jaenisch, Rudolf, et al.
出版: (2014)

The MLL family of proteins in normal development and disease
由: Milne, TA
出版: (2020)

The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis
由: Mahmoudi, T, et al.
出版: (2010)

Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia
由: Akalin, A, et al.
出版: (2012)

Functional studies of Af4 in the robotic mouse.
由: Davies, K, et al.
出版: (2003)