Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits
Chronic sleep disturbances, associated with cardio-metabolic diseases, psychiatric disorders and all-cause mortality1,2, affect 25-30% of adults worldwide. While environmental factors contribute importantly to self-reported habitual sleep duration and disruption, these traits are heritable4-9, and g...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Published: |
Springer Nature
2016
|
| _version_ | 1797051586080407552 |
|---|---|
| author | Lane, J Liang, J Vlasac, I Anderson, S Bechtold, D Bowden, J Emsely, R Gill, S Little, M Luik, A Loudon, A Scheer, F Purcell, S Kyle, S Lawlor, D Zhu, X Redline, S Ray, D Rutter, M Saxena, R |
| author_facet | Lane, J Liang, J Vlasac, I Anderson, S Bechtold, D Bowden, J Emsely, R Gill, S Little, M Luik, A Loudon, A Scheer, F Purcell, S Kyle, S Lawlor, D Zhu, X Redline, S Ray, D Rutter, M Saxena, R |
| author_sort | Lane, J |
| collection | OXFORD |
| description | Chronic sleep disturbances, associated with cardio-metabolic diseases, psychiatric disorders and all-cause mortality1,2, affect 25-30% of adults worldwide. While environmental factors contribute importantly to self-reported habitual sleep duration and disruption, these traits are heritable4-9, and gene identification should improve our understanding of sleep function, mechanisms linking sleep to disease, and development of novel therapies. We report single and multi-trait genome-wide association analyses (GWAS) of self-reported sleep duration, insomnia symptoms including difficulty initiating and/or maintaining sleep, and excessive daytime sleepiness in the UK Biobank (n=112,586), with discovery of loci for insomnia symptoms (near MEIS1, TMEM132E, CYCL1, TGFBI in females and WDR27 in males), excessive daytime sleepiness (near AR/OPHN1) and a composite sleep trait (near INADL and HCRTR2), as well as replication of a locus for sleep duration (at PAX-8). Genetic correlation was observed between longer sleep duration and schizophrenia (rG=0.29, p=1.90x10-13) and between increased excessive daytime sleepiness and increased adiposity traits (BMI rG=0.20,p=3.12x10-09; waist circumference rG=0.20, p=2.12x10-07). |
| first_indexed | 2024-03-06T18:21:37Z |
| format | Journal article |
| id | oxford-uuid:067bf112-a954-466d-8df0-f57debf75b52 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T18:21:37Z |
| publishDate | 2016 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:067bf112-a954-466d-8df0-f57debf75b522022-03-26T09:02:51ZGenome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traitsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:067bf112-a954-466d-8df0-f57debf75b52Symplectic Elements at OxfordSpringer Nature2016Lane, JLiang, JVlasac, IAnderson, SBechtold, DBowden, JEmsely, RGill, SLittle, MLuik, ALoudon, AScheer, FPurcell, SKyle, SLawlor, DZhu, XRedline, SRay, DRutter, MSaxena, RChronic sleep disturbances, associated with cardio-metabolic diseases, psychiatric disorders and all-cause mortality1,2, affect 25-30% of adults worldwide. While environmental factors contribute importantly to self-reported habitual sleep duration and disruption, these traits are heritable4-9, and gene identification should improve our understanding of sleep function, mechanisms linking sleep to disease, and development of novel therapies. We report single and multi-trait genome-wide association analyses (GWAS) of self-reported sleep duration, insomnia symptoms including difficulty initiating and/or maintaining sleep, and excessive daytime sleepiness in the UK Biobank (n=112,586), with discovery of loci for insomnia symptoms (near MEIS1, TMEM132E, CYCL1, TGFBI in females and WDR27 in males), excessive daytime sleepiness (near AR/OPHN1) and a composite sleep trait (near INADL and HCRTR2), as well as replication of a locus for sleep duration (at PAX-8). Genetic correlation was observed between longer sleep duration and schizophrenia (rG=0.29, p=1.90x10-13) and between increased excessive daytime sleepiness and increased adiposity traits (BMI rG=0.20,p=3.12x10-09; waist circumference rG=0.20, p=2.12x10-07). |
| spellingShingle | Lane, J Liang, J Vlasac, I Anderson, S Bechtold, D Bowden, J Emsely, R Gill, S Little, M Luik, A Loudon, A Scheer, F Purcell, S Kyle, S Lawlor, D Zhu, X Redline, S Ray, D Rutter, M Saxena, R Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits |
| title | Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits |
| title_full | Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits |
| title_fullStr | Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits |
| title_full_unstemmed | Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits |
| title_short | Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits |
| title_sort | genome wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits |
| work_keys_str_mv | AT lanej genomewideassociationanalysesofsleepdisturbancetraitsidentifynewlociandhighlightsharedgeneticswithneuropsychiatricandmetabolictraits AT liangj genomewideassociationanalysesofsleepdisturbancetraitsidentifynewlociandhighlightsharedgeneticswithneuropsychiatricandmetabolictraits AT vlasaci genomewideassociationanalysesofsleepdisturbancetraitsidentifynewlociandhighlightsharedgeneticswithneuropsychiatricandmetabolictraits AT andersons genomewideassociationanalysesofsleepdisturbancetraitsidentifynewlociandhighlightsharedgeneticswithneuropsychiatricandmetabolictraits AT bechtoldd genomewideassociationanalysesofsleepdisturbancetraitsidentifynewlociandhighlightsharedgeneticswithneuropsychiatricandmetabolictraits AT bowdenj genomewideassociationanalysesofsleepdisturbancetraitsidentifynewlociandhighlightsharedgeneticswithneuropsychiatricandmetabolictraits AT emselyr genomewideassociationanalysesofsleepdisturbancetraitsidentifynewlociandhighlightsharedgeneticswithneuropsychiatricandmetabolictraits AT gills genomewideassociationanalysesofsleepdisturbancetraitsidentifynewlociandhighlightsharedgeneticswithneuropsychiatricandmetabolictraits AT littlem genomewideassociationanalysesofsleepdisturbancetraitsidentifynewlociandhighlightsharedgeneticswithneuropsychiatricandmetabolictraits AT luika genomewideassociationanalysesofsleepdisturbancetraitsidentifynewlociandhighlightsharedgeneticswithneuropsychiatricandmetabolictraits AT loudona genomewideassociationanalysesofsleepdisturbancetraitsidentifynewlociandhighlightsharedgeneticswithneuropsychiatricandmetabolictraits AT scheerf genomewideassociationanalysesofsleepdisturbancetraitsidentifynewlociandhighlightsharedgeneticswithneuropsychiatricandmetabolictraits AT purcells genomewideassociationanalysesofsleepdisturbancetraitsidentifynewlociandhighlightsharedgeneticswithneuropsychiatricandmetabolictraits AT kyles genomewideassociationanalysesofsleepdisturbancetraitsidentifynewlociandhighlightsharedgeneticswithneuropsychiatricandmetabolictraits AT lawlord genomewideassociationanalysesofsleepdisturbancetraitsidentifynewlociandhighlightsharedgeneticswithneuropsychiatricandmetabolictraits AT zhux genomewideassociationanalysesofsleepdisturbancetraitsidentifynewlociandhighlightsharedgeneticswithneuropsychiatricandmetabolictraits AT redlines genomewideassociationanalysesofsleepdisturbancetraitsidentifynewlociandhighlightsharedgeneticswithneuropsychiatricandmetabolictraits AT rayd genomewideassociationanalysesofsleepdisturbancetraitsidentifynewlociandhighlightsharedgeneticswithneuropsychiatricandmetabolictraits AT rutterm genomewideassociationanalysesofsleepdisturbancetraitsidentifynewlociandhighlightsharedgeneticswithneuropsychiatricandmetabolictraits AT saxenar genomewideassociationanalysesofsleepdisturbancetraitsidentifynewlociandhighlightsharedgeneticswithneuropsychiatricandmetabolictraits |