HCM and DCM mutations in thin filament proteins have opposite effects on regulation of contractility in vitro

HCM and DCM mutations in thin filament proteins have opposite effects on regulation of contractility in vitro

Podrobná bibliografie
Hlavní autoři:	Redwood, C, Robinson, P, Mirza, M, Knott, A, Marston, S, Watkins, H
Médium:	Conference item
Vydáno:	2003

Podobné jednotky

HCM and DCM mutations in cardiac thin filament proteins have opposite effects on the regulation of contractility in vitro
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Vydáno: (2003)

HCM and DCM mutations in thin filament proteins have opposite effects on in vitro motility
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Effects of DCM mutations in thin filament regulatory proteins on contractile function
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In vitro motility studies of HCM and DCM mutations in cardiac muscle actin
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Mutations in tropomyosin that cause DCM, affect cooperativity of cardiac muscle thin filaments
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Two DCM mutations in cardiac tropomyosin alter thin filament function by different mechanisms
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Hypertrophic and dilated cardiomyopathycausing mutations of troponin and alpha-tropomyosin have opposite effects on thin filament calcium binding
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Autosomal dominant HCM and DCM phenotype caused by a novel mutation in phospholamban
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Vydáno: (2004)

Two mutations in troponin I that cause hypertrophic cardiomyopathy have contrasting effects on cardiac muscle contractility.
Autor: Burton, D, a další
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Evidence for haploinsufficiency as the mechanism of action of MyBP-C mutations that cause HCM
Autor: Carballo, S, a další
Vydáno: (2008)

Dilated and hypertrophic cardiomyopathy mutations in troponin and alpha-tropomyosin have opposing effects on the calcium affinity of cardiac thin filaments.
Autor: Robinson, P, a další
Vydáno: (2007)

Dilated cardiomyopathy mutations in thin-filament regulatory proteins reduce contractility, suppress systolic Ca²⁺, and activate NFAT and Akt signaling
Autor: Robinson, P, a další
Vydáno: (2020)

Modulation of thin filament activation by breakdown or isoform switching of thin filament proteins: physiological and pathological implications.
Autor: Marston, S, a další
Vydáno: (2003)

Dilated cardiomyopathy mutations in three thin filament regulatory proteins result in a common functional phenotype.
Autor: Mirza, M, a další
Vydáno: (2005)

Alterations in thin filament regulation induced by a human cardiac troponin T mutant that causes dilated cardiomyopathy are distinct from those induced by troponin T mutants that cause hypertrophic cardiomyopathy.
Autor: Robinson, P, a další
Vydáno: (2002)

The effect of HCM mutations in troponin T and troponin I on the calcium binding of human cardiac troponin
Autor: Redwood, C, a další
Vydáno: (2001)

Functional effects of mutations in troponin T and tropomyosin which cause dilated cardiomyopathy
Autor: Robinson, P, a další
Vydáno: (2003)

MiR-1-3p that correlates with left ventricular function of HCM can serve as a potential target and differentiate HCM from DCM
Autor: Mengmeng Li, a další
Vydáno: (2018-06-01)

Mouse HCM Model Expression E99K ACTC Mutation Reproduces the Clinical HCM Phenotype
Autor: Song, W, a další
Vydáno: (2009)

The effect of mutations in alpha-tropomyosin (E40K and E54K) that cause familial dilated cardiomyopathy on the regulatory mechanism of cardiac muscle thin filaments.
Autor: Mirza, M, a další
Vydáno: (2007)

Using fluorescence emission spectroscopy to asses the Ca2+ affinity of reconstituted troponin and thin filaments containing cardiomyopathy causing mutations of troponin and alpha-tropomyosin
Autor: Robinson, P, a další
Vydáno: (2007)

Mavacamten rescues increased myofilament calcium sensitivity and dysregulation of Ca2+ flux caused by thin filament hypertrophic cardiomyopathy mutations
Autor: Sparrow, AJ, a další
Vydáno: (2020)

A revised method of troponin exchange in permeabilised cardiac trabeculae using vanadate: functional consequences of a HCM-causing mutation in troponin I.
Autor: Preston, L, a další
Vydáno: (2006)

Interaction analyses elucidate the pathophysiology of HCM-causing missense mutations in cardiac myosin binding protein-C.
Autor: Moolman-Smook, J, a další
Vydáno: (2001)

Value of MRI derived parameters in the discrimination of familial left ventricular noncompaction (LVNC), DCM and HCM in comparison to healthy volunteers
Autor: Hassfeld Sabine, a další
Vydáno: (2011-02-01)

Functional investigation of troponin with the homozygous HCM mutation, TNNT2 K280N, obtained from an explanted heart
Autor: Bayliss, C, a další
Vydáno: (2012)

Familial Dilated Cardiomyopathy Caused by an Alpha-Tropomyosin Mutation: The Distinctive Natural History of Sarcomeric DCM
Autor: Lakdawala, N, a další
Vydáno: (2009)

Cardiomyopathy-Causing Mutations in Thin Filament Regulatory Proteins Acutely Affeect Ca2+-Buffering and Ca2+-Dependent Signalling In Situ
Autor: Robinson, P, a další
Vydáno: (2013)

P123The rescue of Ca2+ cycling abnormalities conferred by HCM-causing mutations with analogues of the green tea polyphenol epigallocatechin-3-gallate.
Autor: Robinson, P, a další
Vydáno: (2014)

The HCM-associated cardiac Troponin T mutation K280N causes reduced responsiveness to protein kinase A
Autor: Van Der Velden, J, a další
Vydáno: (2012)

Cardiomyopathy-causing mutations in cardiac thin filament regulatory proteins acutely affect Ca2+ buffering and Ca2+ dependant signalling in situ
Autor: Robinson, P, a další
Vydáno: (2012)

Comparison of the functional effects of mutations in troponin T which cause dilated and hypertrophic cardiomyopathies
Autor: Robinson, P, a další
Vydáno: (2002)

The nemaline myopathy-causing E117K mutation in β-tropomyosin reduces thin filament activation.
Autor: Karpicheva, O, a další
Vydáno: (2013)

Mutations in fast skeletal troponin I, troponin T and beta-tropomyosin that cause distal arthrogryposis all enhance thin filament activation
Autor: Robinson, P, a další
Vydáno: (2005)

A novel interaction between the C5 and C8 domains of myosin binding protein-C and its modulation by HCM mutations
Autor: Flashman, E, a další
Vydáno: (2002)

Investigation of a truncated cardiac troponin T that causes familial hypertrophic cardiomyopathy: Ca(2+) regulatory properties of reconstituted thin filaments depend on the ratio of mutant to wild-type protein.
Autor: Redwood, C, a další
Vydáno: (2000)

Patients with hypertrophic cardiomyopathy (HCM) and HCM gene carriers have attenuated myocardial oxygenation response to vasodilator stress - a potential mechanism for sudden cardiac death.
Autor: Dass, S, a další
Vydáno: (2012)

Investigation of troponin I mutations causing familial hypertrophic cardiomyopathy
Autor: Abdulrazzak, H, a další
Vydáno: (2001)

Effects of hypertrophic cardiomyopathy mutations in troponin I on contractility of skinned cardiac muscle fibres
Autor: Burton, D, a další
Vydáno: (2002)

Functional effects of the DCM mutant Gly159Asp troponin C in skinned muscle fibres.
Autor: Preston, L, a další
Vydáno: (2007)