HCM and DCM mutations in thin filament proteins have opposite effects on regulation of contractility in vitro

HCM and DCM mutations in thin filament proteins have opposite effects on regulation of contractility in vitro

Détails bibliographiques
Auteurs principaux:	Redwood, C, Robinson, P, Mirza, M, Knott, A, Marston, S, Watkins, H
Format:	Conference item
Publié:	2003

Documents similaires

HCM and DCM mutations in cardiac thin filament proteins have opposite effects on the regulation of contractility in vitro
par: Redwood, C, et autres
Publié: (2003)

HCM and DCM mutations in thin filament proteins have opposite effects on in vitro motility
par: Marston, S, et autres
Publié: (2002)

Effects of DCM mutations in thin filament regulatory proteins on contractile function
par: Robinson, P, et autres
Publié: (2005)

In vitro motility studies of HCM and DCM mutations in cardiac muscle actin
par: Dyer, E, et autres
Publié: (2007)

Mutations in tropomyosin that cause DCM, affect cooperativity of cardiac muscle thin filaments
par: Marston, S, et autres
Publié: (2007)

Two DCM mutations in cardiac tropomyosin alter thin filament function by different mechanisms
par: Marston, S, et autres
Publié: (2007)

Hypertrophic and dilated cardiomyopathycausing mutations of troponin and alpha-tropomyosin have opposite effects on thin filament calcium binding
par: Robinson, P, et autres
Publié: (2007)

Autosomal dominant HCM and DCM phenotype caused by a novel mutation in phospholamban
par: Carballo, S, et autres
Publié: (2004)

Two mutations in troponin I that cause hypertrophic cardiomyopathy have contrasting effects on cardiac muscle contractility.
par: Burton, D, et autres
Publié: (2002)

Evidence for haploinsufficiency as the mechanism of action of MyBP-C mutations that cause HCM
par: Carballo, S, et autres
Publié: (2008)

Dilated and hypertrophic cardiomyopathy mutations in troponin and alpha-tropomyosin have opposing effects on the calcium affinity of cardiac thin filaments.
par: Robinson, P, et autres
Publié: (2007)

Dilated cardiomyopathy mutations in thin-filament regulatory proteins reduce contractility, suppress systolic Ca²⁺, and activate NFAT and Akt signaling
par: Robinson, P, et autres
Publié: (2020)

Modulation of thin filament activation by breakdown or isoform switching of thin filament proteins: physiological and pathological implications.
par: Marston, S, et autres
Publié: (2003)

Dilated cardiomyopathy mutations in three thin filament regulatory proteins result in a common functional phenotype.
par: Mirza, M, et autres
Publié: (2005)

Alterations in thin filament regulation induced by a human cardiac troponin T mutant that causes dilated cardiomyopathy are distinct from those induced by troponin T mutants that cause hypertrophic cardiomyopathy.
par: Robinson, P, et autres
Publié: (2002)

The effect of HCM mutations in troponin T and troponin I on the calcium binding of human cardiac troponin
par: Redwood, C, et autres
Publié: (2001)

Functional effects of mutations in troponin T and tropomyosin which cause dilated cardiomyopathy
par: Robinson, P, et autres
Publié: (2003)

MiR-1-3p that correlates with left ventricular function of HCM can serve as a potential target and differentiate HCM from DCM
par: Mengmeng Li, et autres
Publié: (2018-06-01)

Mouse HCM Model Expression E99K ACTC Mutation Reproduces the Clinical HCM Phenotype
par: Song, W, et autres
Publié: (2009)

The effect of mutations in alpha-tropomyosin (E40K and E54K) that cause familial dilated cardiomyopathy on the regulatory mechanism of cardiac muscle thin filaments.
par: Mirza, M, et autres
Publié: (2007)

Using fluorescence emission spectroscopy to asses the Ca2+ affinity of reconstituted troponin and thin filaments containing cardiomyopathy causing mutations of troponin and alpha-tropomyosin
par: Robinson, P, et autres
Publié: (2007)

Mavacamten rescues increased myofilament calcium sensitivity and dysregulation of Ca2+ flux caused by thin filament hypertrophic cardiomyopathy mutations
par: Sparrow, AJ, et autres
Publié: (2020)

A revised method of troponin exchange in permeabilised cardiac trabeculae using vanadate: functional consequences of a HCM-causing mutation in troponin I.
par: Preston, L, et autres
Publié: (2006)

Interaction analyses elucidate the pathophysiology of HCM-causing missense mutations in cardiac myosin binding protein-C.
par: Moolman-Smook, J, et autres
Publié: (2001)

Value of MRI derived parameters in the discrimination of familial left ventricular noncompaction (LVNC), DCM and HCM in comparison to healthy volunteers
par: Hassfeld Sabine, et autres
Publié: (2011-02-01)

Functional investigation of troponin with the homozygous HCM mutation, TNNT2 K280N, obtained from an explanted heart
par: Bayliss, C, et autres
Publié: (2012)

Familial Dilated Cardiomyopathy Caused by an Alpha-Tropomyosin Mutation: The Distinctive Natural History of Sarcomeric DCM
par: Lakdawala, N, et autres
Publié: (2009)

Cardiomyopathy-Causing Mutations in Thin Filament Regulatory Proteins Acutely Affeect Ca2+-Buffering and Ca2+-Dependent Signalling In Situ
par: Robinson, P, et autres
Publié: (2013)

P123The rescue of Ca2+ cycling abnormalities conferred by HCM-causing mutations with analogues of the green tea polyphenol epigallocatechin-3-gallate.
par: Robinson, P, et autres
Publié: (2014)

The HCM-associated cardiac Troponin T mutation K280N causes reduced responsiveness to protein kinase A
par: Van Der Velden, J, et autres
Publié: (2012)

Cardiomyopathy-causing mutations in cardiac thin filament regulatory proteins acutely affect Ca2+ buffering and Ca2+ dependant signalling in situ
par: Robinson, P, et autres
Publié: (2012)

Comparison of the functional effects of mutations in troponin T which cause dilated and hypertrophic cardiomyopathies
par: Robinson, P, et autres
Publié: (2002)

The nemaline myopathy-causing E117K mutation in β-tropomyosin reduces thin filament activation.
par: Karpicheva, O, et autres
Publié: (2013)

Mutations in fast skeletal troponin I, troponin T and beta-tropomyosin that cause distal arthrogryposis all enhance thin filament activation
par: Robinson, P, et autres
Publié: (2005)

A novel interaction between the C5 and C8 domains of myosin binding protein-C and its modulation by HCM mutations
par: Flashman, E, et autres
Publié: (2002)

Investigation of a truncated cardiac troponin T that causes familial hypertrophic cardiomyopathy: Ca(2+) regulatory properties of reconstituted thin filaments depend on the ratio of mutant to wild-type protein.
par: Redwood, C, et autres
Publié: (2000)

Patients with hypertrophic cardiomyopathy (HCM) and HCM gene carriers have attenuated myocardial oxygenation response to vasodilator stress - a potential mechanism for sudden cardiac death.
par: Dass, S, et autres
Publié: (2012)

Investigation of troponin I mutations causing familial hypertrophic cardiomyopathy
par: Abdulrazzak, H, et autres
Publié: (2001)

Effects of hypertrophic cardiomyopathy mutations in troponin I on contractility of skinned cardiac muscle fibres
par: Burton, D, et autres
Publié: (2002)

Functional effects of the DCM mutant Gly159Asp troponin C in skinned muscle fibres.
par: Preston, L, et autres
Publié: (2007)