Deoxyguanosine is a TLR7 agonist

Deoxyguanosine is a TLR7 agonist

Toll-like receptor 7 (TLR7) is an innate immune sensor for single-strand RNA (ssRNA). Recent structural analysis revealed that TLR7 has an additional binding site for nucleosides such as guanosine and is activated when both guanosine and ssRNA bind. The nucleoside binding site also accommodates imid...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính:	Davenne, T, Bridgeman, A, Rigby, R, Rehwinkel, J
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	Wiley 2019

Những quyển sách tương tự

Comparison of human B cell activation by TLR7 and TLR9 agonists
Bằng: Neys Lori, et al.
Được phát hành: (2008-07-01)

The role of TLR7 agonists in modulating COVID-19 severity in subjects with loss-of-function TLR7 variants
Bằng: Shaik Mohammad Naushad, et al.
Được phát hành: (2023-08-01)

Potent adjuvanticity of a pure TLR7-agonistic imidazoquinoline dendrimer.
Bằng: Nikunj M Shukla, et al.
Được phát hành: (2012-01-01)

Molecular dynamics simulations reveal the selectivity mechanism of structurally similar agonists to TLR7 and TLR8.
Bằng: Xiaoyu Wang, et al.
Được phát hành: (2022-01-01)

The TLR7 agonist Imiquimod promote the immunogenicity of msenchymal stem cells
Bằng: Li Zhang, et al.
Được phát hành: (2015-01-01)

PNP inhibitors selectively kill cancer cells lacking SAMHD1
Bằng: Tamara Davenne, et al.
Được phát hành: (2020-11-01)

BBIQ, a pure TLR7 agonist, is an effective influenza vaccine adjuvant
Bằng: Deepender Kaushik, et al.
Được phát hành: (2020-08-01)

Transcriptional networks in plasmacytoid dendritic cells stimulated with synthetic TLR 7 agonists
Bằng: Vasilakos John P, et al.
Được phát hành: (2007-10-01)

Alum and a TLR7 agonist combined with built-in TLR4 and 5 agonists synergistically enhance immune responses against HPV RG1 epitope
Bằng: Maryam Mashhadi Abolghasem Shirazi, et al.
Được phát hành: (2023-10-01)

Varicella-Zoster virus ORF9 Is an antagonist of the DNA sensor cGAS
Bằng: Hertzog, J, et al.
Được phát hành: (2020)

Determining 8-oxo-2’-deoxyguanosine/2’-deoxyguanosine ratio in DNA by reverse phase HPLC combined with amperometric detection
Bằng: D. S. Esipov, et al.
Được phát hành: (2010-06-01)

Synthesis of 8-oxo-7,8-dihydro-2′-deoxyguanosine from 2′-deoxyguanosine using Cu(II)/H2O2/ascorbate: A new strategy for an improved yield
Bằng: Patrícia S. Peres, et al.
Được phát hành: (2016-06-01)

Genomic 8-oxo-7,8-dihydro-2&#39;-deoxyguanosine Quantification
Bằng: Antonio Sarno
Được phát hành: (2013-09-01)

Interferon induction held captive in tumor cells
Bằng: Bridgeman, A, et al.
Được phát hành: (2021)

Innate immune receptors in human airway smooth muscle cells: activation by TLR1/2, TLR3, TLR4, TLR7 and NOD1 agonists.
Bằng: Anne Månsson Kvarnhammar, et al.
Được phát hành: (2013-01-01)

NOD2 Agonist Promotes the Production of Inflammatory Cytokines in VSMC in Synergy with TLR2 and TLR4 Agonists
Bằng: Jinghua Sun, et al.
Được phát hành: (2012-01-01)

Electrophilic Substitution at C(7) of a Protected 7-Deaza-2’-deoxyguanosine – The 2’-Deoxyribonucleoside Parent Analogue of Queuosine #
Bằng: Helmut Rosemeyer, et al.
Được phát hành: (2007-04-01)

Lignin-chitosan-based biocomposite film for the localized delivery of TLR7 agonist imiquimod
Bằng: Aashna Jassal, et al.
Được phát hành: (2024-11-01)

ProLonged Liposomal Delivery of TLR7/8 Agonist for Enhanced Cancer Vaccine
Bằng: Sehui Kim, et al.
Được phát hành: (2023-09-01)

A Therapeutic Whole-Tumor-Cell Vaccine Covalently Conjugated with a TLR7 Agonist
Bằng: Huju Chi, et al.
Được phát hành: (2022-06-01)

8-Oxo-7,8-Dihydro-2′-Deoxyguanosine (8-oxodG) and 8-Hydroxy-2′-Deoxyguanosine (8-OHdG) as a Potential Biomarker for Gestational Diabetes Mellitus (GDM) Development
Bằng: Sandra K. Urbaniak, et al.
Được phát hành: (2020-01-01)

Varicella‐Zoster virus ORF9 is an antagonist of the DNA sensor cGAS
Bằng: Hertzog, J, et al.
Được phát hành: (2022)

Viruses transfer the antiviral second messenger cGAMP between cells
Bằng: Bridgeman, A, et al.
Được phát hành: (2015)

Immunogenicity in humans of a transdermal multipeptide melanoma vaccine administered with or without a TLR7 agonist
Bằng: Craig L Slingluff, et al.
Được phát hành: (2021-05-01)

A TLR7/8 agonist increases efficacy of anti-fentanyl vaccines in rodent and porcine models
Bằng: Bethany Crouse, et al.
Được phát hành: (2023-07-01)

T cell-independent eradication of experimental glioma by intravenous TLR7/8-agonist-loaded nanoparticles
Bằng: Verena Turco, et al.
Được phát hành: (2023-02-01)

Biotinylation of Deoxyguanosine at the Abasic Site in Double-Stranded Oligodeoxynucleotides
Bằng: Chun Wu
Được phát hành: (2016-01-01)

Mitochondrial deoxyguanosine kinase is required for female fertility in mice
Bằng: Gao Yake, et al.
Được phát hành: (2024-02-01)

1161 Development of TLR7- and STING-conjugatable agonists for immunostimulatory ADC-based cancer therapies
Bằng: Fabienne Vernejoul, et al.
Được phát hành: (2023-11-01)

8-Oxo-2’-deoxyguanosine – biomarker of the oxidative stress
Bằng: T. S. Nevredimova, et al.
Được phát hành: (2014-10-01)

Sequence-Dependent Variation in the Reactivity of 8-Oxo-7,8-dihydro-2′-deoxyguanosine toward Oxidation
Bằng: Lim, Kok Seong, et al.
Được phát hành: (2014)

Formulated Phospholipids as Non-Canonical TLR4 Agonists
Bằng: Hong Liang, et al.
Được phát hành: (2022-11-01)

The mechanism of decomposition of N-methyl-N-nitrosourea (MNU) in water and a study of its reactions with 2'-deoxyguanosine, 2'-deoxyguanosine 5'-monophosphate and d(GTGCAC)
Bằng: Golding, B, et al.
Được phát hành: (1997)

Deoxyguanosine kinase deficiency: natural history and liver transplant outcome
Bằng: Manzoni, E, et al.
Được phát hành: (2024)

Employing Drug Delivery Strategies to Overcome Challenges Using TLR7/8 Agonists for Cancer Immunotherapy
Bằng: Varshney, Dhruv, et al.
Được phát hành: (2022)

Employing Drug Delivery Strategies to Overcome Challenges Using TLR7/8 Agonists for Cancer Immunotherapy
Bằng: Varshney, Dhruv, et al.
Được phát hành: (2021)

Safety, tolerability, pharmacokinetics, and pharmacodynamics of a TLR7 agonist prodrug RO6870868 in healthy volunteers
Bằng: Joseph F. Grippo, et al.
Được phát hành: (2021-07-01)

Identifying the Tautomeric Form of a Deoxyguanosine-Estrogen Quinone Intermediate
Bằng: Douglas E. Stack
Được phát hành: (2015-09-01)

Atherosclerosis induced by endogenous and exogenous toll-like receptor (TLR)1 or TLR6 agonists
Bằng: Linda K. Curtiss, et al.
Được phát hành: (2012-10-01)

The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer
Bằng: Katherine A. Michaelis, et al.
Được phát hành: (2019-10-01)