Deoxyguanosine is a TLR7 agonist

Toll-like receptor 7 (TLR7) is an innate immune sensor for single-strand RNA (ssRNA). Recent structural analysis revealed that TLR7 has an additional binding site for nucleosides such as guanosine and is activated when both guanosine and ssRNA bind. The nucleoside binding site also accommodates imid...

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Bibliographic Details
Main Authors: Davenne, T, Bridgeman, A, Rigby, R, Rehwinkel, J
Format: Journal article
Language:English
Published: Wiley 2019