Mental health and well-being of older adults living with HIV in sub-Saharan Africa: a systematic review
<br><strong>Objective</strong> In this systematic review, we aimed to summarise the empirical evidence on common mental disorders (CMDs), cognitive impairment, frailty and health-related quality of life (HRQoL) among people living with HIV aged ≥50 years (PLWH50 +) residing in sub-...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
BMJ Publishing Group
2021
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| _version_ | 1797051715217784832 |
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| author | Mwangala, PN Mabrouk, A Wagner, R Newton, CRJC Abubakar, AA |
| author_facet | Mwangala, PN Mabrouk, A Wagner, R Newton, CRJC Abubakar, AA |
| author_sort | Mwangala, PN |
| collection | OXFORD |
| description | <br><strong>Objective</strong> In this systematic review, we aimed to summarise the empirical evidence on common mental disorders (CMDs), cognitive impairment, frailty and health-related quality of life (HRQoL) among people living with HIV aged ≥50 years (PLWH50 +) residing in sub-Saharan Africa (SSA). Specifically, we document the prevalence and correlates of these outcomes.
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Design, data sources and eligibility criteria </strong>The following online databases were systematically searched: PubMed, CINAHL, PsycINFO, Embase and Scopus up to January 2021. English-language publications on depression, anxiety, cognitive function, frailty and quality of life among PLWH50+ residing in SSA were included.
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Data extraction and synthesis </strong>We extracted information, including study characteristics and main findings. These were tabulated, and a narrative synthesis approach was adopted, given the substantial heterogeneity among included studies.
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Results </strong>A total of 50 studies from fifteen SSA countries met the inclusion criteria. About two-thirds of these studies emanated from Ethiopia, Uganda and South Africa. Studies regarding depression predominated (n=26), followed by cognitive impairment (n=13). Overall, PLWH50+ exhibited varying prevalence of depression (6%–59%), cognitive impairments (4%–61%) and frailty (3%–15%). The correlates of CMDs, cognitive impairment, frailty and HRQoL were rarely investigated, but those reported were sociodemographic variables, many of which were inconsistent.
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Conclusions </strong>This review documented an increasing number of published studies on HIV and ageing from SSA. However, the current evidence on the mental and well-being outcomes in PLWH50+ is inadequate to characterise the public health dimension of these impairments in SSA, because of heterogeneous findings, few well-designed studies and substantial methodological limitations in many of the available studies. Future work should have sufficiently large samples of PLWH50+, engage appropriate comparison groups, harmonise the measurement of these outcomes using a standardised methodology to generate more robust prevalence estimates and confirm predictors.
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PROSPERO registration number </strong>CRD42020145791. |
| first_indexed | 2024-03-06T18:23:24Z |
| format | Journal article |
| id | oxford-uuid:0715a425-f5bc-4df3-8e5a-169e6f37e7e4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:23:24Z |
| publishDate | 2021 |
| publisher | BMJ Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:0715a425-f5bc-4df3-8e5a-169e6f37e7e42022-03-26T09:05:53ZMental health and well-being of older adults living with HIV in sub-Saharan Africa: a systematic reviewJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0715a425-f5bc-4df3-8e5a-169e6f37e7e4EnglishSymplectic ElementsBMJ Publishing Group2021Mwangala, PNMabrouk, AWagner, RNewton, CRJCAbubakar, AA<br><strong>Objective</strong> In this systematic review, we aimed to summarise the empirical evidence on common mental disorders (CMDs), cognitive impairment, frailty and health-related quality of life (HRQoL) among people living with HIV aged ≥50 years (PLWH50 +) residing in sub-Saharan Africa (SSA). Specifically, we document the prevalence and correlates of these outcomes. <br><strong> Design, data sources and eligibility criteria </strong>The following online databases were systematically searched: PubMed, CINAHL, PsycINFO, Embase and Scopus up to January 2021. English-language publications on depression, anxiety, cognitive function, frailty and quality of life among PLWH50+ residing in SSA were included. <br><strong> Data extraction and synthesis </strong>We extracted information, including study characteristics and main findings. These were tabulated, and a narrative synthesis approach was adopted, given the substantial heterogeneity among included studies. <br><strong> Results </strong>A total of 50 studies from fifteen SSA countries met the inclusion criteria. About two-thirds of these studies emanated from Ethiopia, Uganda and South Africa. Studies regarding depression predominated (n=26), followed by cognitive impairment (n=13). Overall, PLWH50+ exhibited varying prevalence of depression (6%–59%), cognitive impairments (4%–61%) and frailty (3%–15%). The correlates of CMDs, cognitive impairment, frailty and HRQoL were rarely investigated, but those reported were sociodemographic variables, many of which were inconsistent. <br><strong> Conclusions </strong>This review documented an increasing number of published studies on HIV and ageing from SSA. However, the current evidence on the mental and well-being outcomes in PLWH50+ is inadequate to characterise the public health dimension of these impairments in SSA, because of heterogeneous findings, few well-designed studies and substantial methodological limitations in many of the available studies. Future work should have sufficiently large samples of PLWH50+, engage appropriate comparison groups, harmonise the measurement of these outcomes using a standardised methodology to generate more robust prevalence estimates and confirm predictors. <br><strong> PROSPERO registration number </strong>CRD42020145791. |
| spellingShingle | Mwangala, PN Mabrouk, A Wagner, R Newton, CRJC Abubakar, AA Mental health and well-being of older adults living with HIV in sub-Saharan Africa: a systematic review |
| title | Mental health and well-being of older adults living with HIV in sub-Saharan Africa: a systematic review |
| title_full | Mental health and well-being of older adults living with HIV in sub-Saharan Africa: a systematic review |
| title_fullStr | Mental health and well-being of older adults living with HIV in sub-Saharan Africa: a systematic review |
| title_full_unstemmed | Mental health and well-being of older adults living with HIV in sub-Saharan Africa: a systematic review |
| title_short | Mental health and well-being of older adults living with HIV in sub-Saharan Africa: a systematic review |
| title_sort | mental health and well being of older adults living with hiv in sub saharan africa a systematic review |
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