Diagnosing and engineering gut microbiomes
The microbes, nutrients and toxins that we are exposed to can have a profound effect on the composition and function of the gut microbiome. Thousands of peer-reviewed publications link microbiome composition and function to health from the moment of birth, right through to centenarians, generating a...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Springer
2024
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| _version_ | 1826315090525159424 |
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| author | Cappio Barazzone, E Diard, M Hug, I Larsson, L Slack, E |
| author_facet | Cappio Barazzone, E Diard, M Hug, I Larsson, L Slack, E |
| author_sort | Cappio Barazzone, E |
| collection | OXFORD |
| description | The microbes, nutrients and toxins that we are exposed to can have a profound effect on the composition and function of the gut microbiome. Thousands of peer-reviewed publications link microbiome composition and function to health from the moment of birth, right through to centenarians, generating a tantalizing glimpse of what might be possible if we could intervene rationally. Nevertheless, there remain relatively few real-world examples where successful microbiome engineering leads to beneficial health effects. Here we aim to provide a framework for the progress needed to turn gut microbiome engineering from a trial-and-error approach to a rational medical intervention. The workflow starts with truly understanding and accurately diagnosing the problems that we are trying to fix, before moving on to developing technologies that can achieve the desired changes. |
| first_indexed | 2024-12-09T03:21:01Z |
| format | Journal article |
| id | oxford-uuid:071cb423-284f-4b5c-89d4-295be04717db |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-12-09T03:21:01Z |
| publishDate | 2024 |
| publisher | Springer |
| record_format | dspace |
| spelling | oxford-uuid:071cb423-284f-4b5c-89d4-295be04717db2024-11-11T20:07:39ZDiagnosing and engineering gut microbiomesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:071cb423-284f-4b5c-89d4-295be04717dbEnglishJisc Publications RouterSpringer2024Cappio Barazzone, EDiard, MHug, ILarsson, LSlack, EThe microbes, nutrients and toxins that we are exposed to can have a profound effect on the composition and function of the gut microbiome. Thousands of peer-reviewed publications link microbiome composition and function to health from the moment of birth, right through to centenarians, generating a tantalizing glimpse of what might be possible if we could intervene rationally. Nevertheless, there remain relatively few real-world examples where successful microbiome engineering leads to beneficial health effects. Here we aim to provide a framework for the progress needed to turn gut microbiome engineering from a trial-and-error approach to a rational medical intervention. The workflow starts with truly understanding and accurately diagnosing the problems that we are trying to fix, before moving on to developing technologies that can achieve the desired changes. |
| spellingShingle | Cappio Barazzone, E Diard, M Hug, I Larsson, L Slack, E Diagnosing and engineering gut microbiomes |
| title | Diagnosing and engineering gut microbiomes |
| title_full | Diagnosing and engineering gut microbiomes |
| title_fullStr | Diagnosing and engineering gut microbiomes |
| title_full_unstemmed | Diagnosing and engineering gut microbiomes |
| title_short | Diagnosing and engineering gut microbiomes |
| title_sort | diagnosing and engineering gut microbiomes |
| work_keys_str_mv | AT cappiobarazzonee diagnosingandengineeringgutmicrobiomes AT diardm diagnosingandengineeringgutmicrobiomes AT hugi diagnosingandengineeringgutmicrobiomes AT larssonl diagnosingandengineeringgutmicrobiomes AT slacke diagnosingandengineeringgutmicrobiomes |