Lithium amide conjugate addition for the asymmetric synthesis of 3-aminopyrrolidines.
Conjugate addition of homochiral lithium amides to methyl 4-(N-benzyl-N-allylamino)but-2-enoate, chemoselective N-deprotection and concomitant cyclisation, followed by enolate functionalisation and deprotection allows access to syn- and anti-3,4-disubstituted aminopyrrolidines in > 98% d.e. a...
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| Príomhchruthaitheoirí: |
Davies, S,
Garner, A,
Goddard, E,
Kruchinin, D,
Roberts, P,
Rodriguez-Solla, H,
Smith, A |
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| Formáid: | Journal article
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| Teanga: | English |
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| Foilsithe / Cruthaithe: |
2006
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