Lithium amide conjugate addition for the asymmetric synthesis of 3-aminopyrrolidines.
Conjugate addition of homochiral lithium amides to methyl 4-(N-benzyl-N-allylamino)but-2-enoate, chemoselective N-deprotection and concomitant cyclisation, followed by enolate functionalisation and deprotection allows access to syn- and anti-3,4-disubstituted aminopyrrolidines in > 98% d.e. a...
詳細記述
書誌詳細
| 主要な著者: |
Davies, S,
Garner, A,
Goddard, E,
Kruchinin, D,
Roberts, P,
Rodriguez-Solla, H,
Smith, A |
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| フォーマット: | Journal article
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| 言語: | English |
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| 出版事項: |
2006
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