Lithium amide conjugate addition for the asymmetric synthesis of 3-aminopyrrolidines.
Conjugate addition of homochiral lithium amides to methyl 4-(N-benzyl-N-allylamino)but-2-enoate, chemoselective N-deprotection and concomitant cyclisation, followed by enolate functionalisation and deprotection allows access to syn- and anti-3,4-disubstituted aminopyrrolidines in > 98% d.e. a...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2006
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| _version_ | 1826257780527333376 |
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| author | Davies, S Garner, A Goddard, E Kruchinin, D Roberts, P Rodriguez-Solla, H Smith, A |
| author_facet | Davies, S Garner, A Goddard, E Kruchinin, D Roberts, P Rodriguez-Solla, H Smith, A |
| author_sort | Davies, S |
| collection | OXFORD |
| description | Conjugate addition of homochiral lithium amides to methyl 4-(N-benzyl-N-allylamino)but-2-enoate, chemoselective N-deprotection and concomitant cyclisation, followed by enolate functionalisation and deprotection allows access to syn- and anti-3,4-disubstituted aminopyrrolidines in > 98% d.e. and > 98% e.e. |
| first_indexed | 2024-03-06T18:23:36Z |
| format | Journal article |
| id | oxford-uuid:072aa7db-8a9f-47c5-a8b9-5abe7f8e2bc3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:23:36Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:072aa7db-8a9f-47c5-a8b9-5abe7f8e2bc32022-03-26T09:06:13ZLithium amide conjugate addition for the asymmetric synthesis of 3-aminopyrrolidines.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:072aa7db-8a9f-47c5-a8b9-5abe7f8e2bc3EnglishSymplectic Elements at Oxford2006Davies, SGarner, AGoddard, EKruchinin, DRoberts, PRodriguez-Solla, HSmith, AConjugate addition of homochiral lithium amides to methyl 4-(N-benzyl-N-allylamino)but-2-enoate, chemoselective N-deprotection and concomitant cyclisation, followed by enolate functionalisation and deprotection allows access to syn- and anti-3,4-disubstituted aminopyrrolidines in > 98% d.e. and > 98% e.e. |
| spellingShingle | Davies, S Garner, A Goddard, E Kruchinin, D Roberts, P Rodriguez-Solla, H Smith, A Lithium amide conjugate addition for the asymmetric synthesis of 3-aminopyrrolidines. |
| title | Lithium amide conjugate addition for the asymmetric synthesis of 3-aminopyrrolidines. |
| title_full | Lithium amide conjugate addition for the asymmetric synthesis of 3-aminopyrrolidines. |
| title_fullStr | Lithium amide conjugate addition for the asymmetric synthesis of 3-aminopyrrolidines. |
| title_full_unstemmed | Lithium amide conjugate addition for the asymmetric synthesis of 3-aminopyrrolidines. |
| title_short | Lithium amide conjugate addition for the asymmetric synthesis of 3-aminopyrrolidines. |
| title_sort | lithium amide conjugate addition for the asymmetric synthesis of 3 aminopyrrolidines |
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