Lithium amide conjugate addition for the asymmetric synthesis of 3-aminopyrrolidines.

Lithium amide conjugate addition for the asymmetric synthesis of 3-aminopyrrolidines.

Conjugate addition of homochiral lithium amides to methyl 4-(N-benzyl-N-allylamino)but-2-enoate, chemoselective N-deprotection and concomitant cyclisation, followed by enolate functionalisation and deprotection allows access to syn- and anti-3,4-disubstituted aminopyrrolidines in > 98% d.e. a...

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Detalles Bibliográficos
Main Authors:	Davies, S, Garner, A, Goddard, E, Kruchinin, D, Roberts, P, Rodriguez-Solla, H, Smith, A
Formato:	Journal article
Idioma:	English
Publicado:	2006

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