Increased expression of the diabetes gene SOX4 reduces insulin secretion by impaired fusion pore expansion

Increased expression of the diabetes gene SOX4 reduces insulin secretion by impaired fusion pore expansion

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The transcription factor Sox4 has been proposed to underlie the increased type-2 diabetes risk linked to an intronic SNP in CDKAL1. In a mouse model expressing a mutant form of Sox4, glucose-induced insulin secretion is reduced by 40% despite normal intracellular Ca(2+) signalling and depolarization...

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Autors principals:	Collins, S, Do, H, Hastoy, B, Hugill, A, Adam, J, Chibalina, M, Galvanovskis, J, Godazgar, M, Lee, S, Goldsworthy, M, Salehi, A, Tarasov, A, Rosengren, A, Cox, R, Rorsman, P
Format:	Journal article
Idioma:	English
Publicat:	American Diabetes Association 2016

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