Increased expression of the diabetes gene SOX4 reduces insulin secretion by impaired fusion pore expansion
The transcription factor Sox4 has been proposed to underlie the increased type-2 diabetes risk linked to an intronic SNP in CDKAL1. In a mouse model expressing a mutant form of Sox4, glucose-induced insulin secretion is reduced by 40% despite normal intracellular Ca(2+) signalling and depolarization...
Հիմնական հեղինակներ: | Collins, S, Do, H, Hastoy, B, Hugill, A, Adam, J, Chibalina, M, Galvanovskis, J, Godazgar, M, Lee, S, Goldsworthy, M, Salehi, A, Tarasov, A, Rosengren, A, Cox, R, Rorsman, P |
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Ձևաչափ: | Journal article |
Լեզու: | English |
Հրապարակվել է: |
American Diabetes Association
2016
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