Acute arsenic poisoning: absence of polyneuropathy after treatment with 2,3-dimercaptopropanesulphonate (DMPS).
Two men aged 19 and 21 years ingested 1 g and 4 g respectively from 3 kg of a white crystalline powder that they thought was a substance of abuse. It was later identified as almost pure arsenic trioxide. Both had nausea and vomiting and one developed acute renal failure. Each was treated with 2,3-di...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1994
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| _version_ | 1797051779073966080 |
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| author | Moore, D O'Callaghan, C Berlyne, G Ogg, C Davies, H House, I Henry, J |
| author_facet | Moore, D O'Callaghan, C Berlyne, G Ogg, C Davies, H House, I Henry, J |
| author_sort | Moore, D |
| collection | OXFORD |
| description | Two men aged 19 and 21 years ingested 1 g and 4 g respectively from 3 kg of a white crystalline powder that they thought was a substance of abuse. It was later identified as almost pure arsenic trioxide. Both had nausea and vomiting and one developed acute renal failure. Each was treated with 2,3-dimercaptopropanesulphonate (DMPS), and made a full recovery with no evidence of prolonged renal or neurological impairment. The DMPS-arsenic complex is probably associated with lower penetration into the CNS and as a consequence treatment with DMPS may result in lower acute and chronic neurotoxicity than treatment with the currently standard recommended chelating agent dimercaprol (British Anti-Lewisite; BAL). |
| first_indexed | 2024-03-06T18:24:16Z |
| format | Journal article |
| id | oxford-uuid:0765ddd0-8109-4ce7-bea0-7404a7b9e284 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:24:16Z |
| publishDate | 1994 |
| record_format | dspace |
| spelling | oxford-uuid:0765ddd0-8109-4ce7-bea0-7404a7b9e2842022-03-26T09:07:18ZAcute arsenic poisoning: absence of polyneuropathy after treatment with 2,3-dimercaptopropanesulphonate (DMPS).Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:0765ddd0-8109-4ce7-bea0-7404a7b9e284EnglishSymplectic Elements at Oxford1994Moore, DO'Callaghan, CBerlyne, GOgg, CDavies, HHouse, IHenry, JTwo men aged 19 and 21 years ingested 1 g and 4 g respectively from 3 kg of a white crystalline powder that they thought was a substance of abuse. It was later identified as almost pure arsenic trioxide. Both had nausea and vomiting and one developed acute renal failure. Each was treated with 2,3-dimercaptopropanesulphonate (DMPS), and made a full recovery with no evidence of prolonged renal or neurological impairment. The DMPS-arsenic complex is probably associated with lower penetration into the CNS and as a consequence treatment with DMPS may result in lower acute and chronic neurotoxicity than treatment with the currently standard recommended chelating agent dimercaprol (British Anti-Lewisite; BAL). |
| spellingShingle | Moore, D O'Callaghan, C Berlyne, G Ogg, C Davies, H House, I Henry, J Acute arsenic poisoning: absence of polyneuropathy after treatment with 2,3-dimercaptopropanesulphonate (DMPS). |
| title | Acute arsenic poisoning: absence of polyneuropathy after treatment with 2,3-dimercaptopropanesulphonate (DMPS). |
| title_full | Acute arsenic poisoning: absence of polyneuropathy after treatment with 2,3-dimercaptopropanesulphonate (DMPS). |
| title_fullStr | Acute arsenic poisoning: absence of polyneuropathy after treatment with 2,3-dimercaptopropanesulphonate (DMPS). |
| title_full_unstemmed | Acute arsenic poisoning: absence of polyneuropathy after treatment with 2,3-dimercaptopropanesulphonate (DMPS). |
| title_short | Acute arsenic poisoning: absence of polyneuropathy after treatment with 2,3-dimercaptopropanesulphonate (DMPS). |
| title_sort | acute arsenic poisoning absence of polyneuropathy after treatment with 2 3 dimercaptopropanesulphonate dmps |
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