Dietary Supplementation with Homoarginine Preserves Cardiac Function in a Murine Model of Post-Myocardial Infarction Heart Failure
Low plasma homoarginine (HA) is an emerging biomarker for cardiovascular disease and an independent predictor of mortality in patients with heart failure. Plasma levels appear to reflect cardiac dysfunction, positively correlating with ejection fraction and inversely with circulating brain natriuret...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
American Heart Association
2017
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| _version_ | 1826257838761050112 |
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| author | Atzler, D McAndrew, D Cordts, K Schneider, J Zervou, S Schwedhelm, E Neubauer, S Lygate, C |
| author_facet | Atzler, D McAndrew, D Cordts, K Schneider, J Zervou, S Schwedhelm, E Neubauer, S Lygate, C |
| author_sort | Atzler, D |
| collection | OXFORD |
| description | Low plasma homoarginine (HA) is an emerging biomarker for cardiovascular disease and an independent predictor of mortality in patients with heart failure. Plasma levels appear to reflect cardiac dysfunction, positively correlating with ejection fraction and inversely with circulating brain natriuretic peptide. However, whether this outcome is a bystander or cause-and-effect has yet to be established. Within the context of stroke, a direct causal relationship has been inferred because normal mice pretreated with 14 mg/L HA had a smaller stroke size. In the present study, we show for the first time that dietary supplementation with HA improves cardiac function in the setting of chronic heart failure, suggesting a novel preventive strategy and inferring that low HA levels may be inherently detrimental because of a loss of this effect. |
| first_indexed | 2024-03-06T18:24:31Z |
| format | Journal article |
| id | oxford-uuid:077b7829-5cff-478d-b5c3-95f3d52629ff |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:24:31Z |
| publishDate | 2017 |
| publisher | American Heart Association |
| record_format | dspace |
| spelling | oxford-uuid:077b7829-5cff-478d-b5c3-95f3d52629ff2022-03-26T09:07:46ZDietary Supplementation with Homoarginine Preserves Cardiac Function in a Murine Model of Post-Myocardial Infarction Heart FailureJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:077b7829-5cff-478d-b5c3-95f3d52629ffEnglishSymplectic Elements at OxfordAmerican Heart Association2017Atzler, DMcAndrew, DCordts, KSchneider, JZervou, SSchwedhelm, ENeubauer, SLygate, CLow plasma homoarginine (HA) is an emerging biomarker for cardiovascular disease and an independent predictor of mortality in patients with heart failure. Plasma levels appear to reflect cardiac dysfunction, positively correlating with ejection fraction and inversely with circulating brain natriuretic peptide. However, whether this outcome is a bystander or cause-and-effect has yet to be established. Within the context of stroke, a direct causal relationship has been inferred because normal mice pretreated with 14 mg/L HA had a smaller stroke size. In the present study, we show for the first time that dietary supplementation with HA improves cardiac function in the setting of chronic heart failure, suggesting a novel preventive strategy and inferring that low HA levels may be inherently detrimental because of a loss of this effect. |
| spellingShingle | Atzler, D McAndrew, D Cordts, K Schneider, J Zervou, S Schwedhelm, E Neubauer, S Lygate, C Dietary Supplementation with Homoarginine Preserves Cardiac Function in a Murine Model of Post-Myocardial Infarction Heart Failure |
| title | Dietary Supplementation with Homoarginine Preserves Cardiac Function in a Murine Model of Post-Myocardial Infarction Heart Failure |
| title_full | Dietary Supplementation with Homoarginine Preserves Cardiac Function in a Murine Model of Post-Myocardial Infarction Heart Failure |
| title_fullStr | Dietary Supplementation with Homoarginine Preserves Cardiac Function in a Murine Model of Post-Myocardial Infarction Heart Failure |
| title_full_unstemmed | Dietary Supplementation with Homoarginine Preserves Cardiac Function in a Murine Model of Post-Myocardial Infarction Heart Failure |
| title_short | Dietary Supplementation with Homoarginine Preserves Cardiac Function in a Murine Model of Post-Myocardial Infarction Heart Failure |
| title_sort | dietary supplementation with homoarginine preserves cardiac function in a murine model of post myocardial infarction heart failure |
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