Genome analysis of the platypus reveals unique signatures of evolution.
We present a draft genome sequence of the platypus, Ornithorhynchus anatinus. This monotreme exhibits a fascinating combination of reptilian and mammalian characters. For example, platypuses have a coat of fur adapted to an aquatic lifestyle; platypus females lactate, yet lay eggs; and males are equ...
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| フォーマット: | Journal article |
| 言語: | English |
| 出版事項: |
2008
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| _version_ | 1826257839921823744 |
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| author | Warren, W Hillier, L Marshall Graves, J Birney, E Ponting, C Grützner, F Belov, K Miller, W Clarke, L Chinwalla, A Yang, S Heger, A Locke, D Miethke, P Waters, P Veyrunes, F Fulton, L Fulton, B Graves, T Wallis, J Puente, X López-Otín, C Ordóñez, G Eichler, E Chen, L Cheng, Z Deakin, J Alsop, A Thompson, K Kirby, P Papenfuss, A Wakefield, M Olender, T Lancet, D Huttley, G Smit, A Pask, A Temple-Smith, P Batzer, M Walker, J Konkel, M Harris, R Whittington, C Wong, E Gemmell, N Buschiazzo, E Vargas Jentzsch, I Merkel, A Schmitz, J Zemann, A Churakov, G Kriegs, J Brosius, J Murchison, E Sachidanandam, R Smith, C Hannon, G Tsend-Ayush, E McMillan, D Attenborough, R Rens, W Ferguson-Smith, M Lefèvre, C Sharp, J Nicholas, K Ray, D Kube, M Reinhardt, R Pringle, T Taylor, J Jones, R Nixon, B Dacheux, J Niwa, H Sekita, Y Huang, X Stark, A Kheradpour, P Kellis, M Flicek, P Chen, Y Webber, C Hardison, R Nelson, J Hallsworth-Pepin, K Delehaunty, K Markovic, C Minx, P Feng, Y Kremitzki, C Mitreva, M Glasscock, J Wylie, T Wohldmann, P Thiru, P Nhan, M Pohl, C Smith, S Hou, S Nefedov, M de Jong, P Renfree, M Mardis, E Wilson, R |
| author_facet | Warren, W Hillier, L Marshall Graves, J Birney, E Ponting, C Grützner, F Belov, K Miller, W Clarke, L Chinwalla, A Yang, S Heger, A Locke, D Miethke, P Waters, P Veyrunes, F Fulton, L Fulton, B Graves, T Wallis, J Puente, X López-Otín, C Ordóñez, G Eichler, E Chen, L Cheng, Z Deakin, J Alsop, A Thompson, K Kirby, P Papenfuss, A Wakefield, M Olender, T Lancet, D Huttley, G Smit, A Pask, A Temple-Smith, P Batzer, M Walker, J Konkel, M Harris, R Whittington, C Wong, E Gemmell, N Buschiazzo, E Vargas Jentzsch, I Merkel, A Schmitz, J Zemann, A Churakov, G Kriegs, J Brosius, J Murchison, E Sachidanandam, R Smith, C Hannon, G Tsend-Ayush, E McMillan, D Attenborough, R Rens, W Ferguson-Smith, M Lefèvre, C Sharp, J Nicholas, K Ray, D Kube, M Reinhardt, R Pringle, T Taylor, J Jones, R Nixon, B Dacheux, J Niwa, H Sekita, Y Huang, X Stark, A Kheradpour, P Kellis, M Flicek, P Chen, Y Webber, C Hardison, R Nelson, J Hallsworth-Pepin, K Delehaunty, K Markovic, C Minx, P Feng, Y Kremitzki, C Mitreva, M Glasscock, J Wylie, T Wohldmann, P Thiru, P Nhan, M Pohl, C Smith, S Hou, S Nefedov, M de Jong, P Renfree, M Mardis, E Wilson, R |
| author_sort | Warren, W |
| collection | OXFORD |
| description | We present a draft genome sequence of the platypus, Ornithorhynchus anatinus. This monotreme exhibits a fascinating combination of reptilian and mammalian characters. For example, platypuses have a coat of fur adapted to an aquatic lifestyle; platypus females lactate, yet lay eggs; and males are equipped with venom similar to that of reptiles. Analysis of the first monotreme genome aligned these features with genetic innovations. We find that reptile and platypus venom proteins have been co-opted independently from the same gene families; milk protein genes are conserved despite platypuses laying eggs; and immune gene family expansions are directly related to platypus biology. Expansions of protein, non-protein-coding RNA and microRNA families, as well as repeat elements, are identified. Sequencing of this genome now provides a valuable resource for deep mammalian comparative analyses, as well as for monotreme biology and conservation. |
| first_indexed | 2024-03-06T18:24:32Z |
| format | Journal article |
| id | oxford-uuid:077d1e07-7034-4cfe-bbe1-153208a7e8dc |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T18:24:32Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:077d1e07-7034-4cfe-bbe1-153208a7e8dc2022-03-26T09:07:57ZGenome analysis of the platypus reveals unique signatures of evolution.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:077d1e07-7034-4cfe-bbe1-153208a7e8dcEnglishSymplectic Elements at Oxford2008Warren, WHillier, LMarshall Graves, JBirney, EPonting, CGrützner, FBelov, KMiller, WClarke, LChinwalla, AYang, SHeger, ALocke, DMiethke, PWaters, PVeyrunes, FFulton, LFulton, BGraves, TWallis, JPuente, XLópez-Otín, COrdóñez, GEichler, EChen, LCheng, ZDeakin, JAlsop, AThompson, KKirby, PPapenfuss, AWakefield, MOlender, TLancet, DHuttley, GSmit, APask, ATemple-Smith, PBatzer, MWalker, JKonkel, MHarris, RWhittington, CWong, EGemmell, NBuschiazzo, EVargas Jentzsch, IMerkel, ASchmitz, JZemann, AChurakov, GKriegs, JBrosius, JMurchison, ESachidanandam, RSmith, CHannon, GTsend-Ayush, EMcMillan, DAttenborough, RRens, WFerguson-Smith, MLefèvre, CSharp, JNicholas, KRay, DKube, MReinhardt, RPringle, TTaylor, JJones, RNixon, BDacheux, JNiwa, HSekita, YHuang, XStark, AKheradpour, PKellis, MFlicek, PChen, YWebber, CHardison, RNelson, JHallsworth-Pepin, KDelehaunty, KMarkovic, CMinx, PFeng, YKremitzki, CMitreva, MGlasscock, JWylie, TWohldmann, PThiru, PNhan, MPohl, CSmith, SHou, SNefedov, Mde Jong, PRenfree, MMardis, EWilson, RWe present a draft genome sequence of the platypus, Ornithorhynchus anatinus. This monotreme exhibits a fascinating combination of reptilian and mammalian characters. For example, platypuses have a coat of fur adapted to an aquatic lifestyle; platypus females lactate, yet lay eggs; and males are equipped with venom similar to that of reptiles. Analysis of the first monotreme genome aligned these features with genetic innovations. We find that reptile and platypus venom proteins have been co-opted independently from the same gene families; milk protein genes are conserved despite platypuses laying eggs; and immune gene family expansions are directly related to platypus biology. Expansions of protein, non-protein-coding RNA and microRNA families, as well as repeat elements, are identified. Sequencing of this genome now provides a valuable resource for deep mammalian comparative analyses, as well as for monotreme biology and conservation. |
| spellingShingle | Warren, W Hillier, L Marshall Graves, J Birney, E Ponting, C Grützner, F Belov, K Miller, W Clarke, L Chinwalla, A Yang, S Heger, A Locke, D Miethke, P Waters, P Veyrunes, F Fulton, L Fulton, B Graves, T Wallis, J Puente, X López-Otín, C Ordóñez, G Eichler, E Chen, L Cheng, Z Deakin, J Alsop, A Thompson, K Kirby, P Papenfuss, A Wakefield, M Olender, T Lancet, D Huttley, G Smit, A Pask, A Temple-Smith, P Batzer, M Walker, J Konkel, M Harris, R Whittington, C Wong, E Gemmell, N Buschiazzo, E Vargas Jentzsch, I Merkel, A Schmitz, J Zemann, A Churakov, G Kriegs, J Brosius, J Murchison, E Sachidanandam, R Smith, C Hannon, G Tsend-Ayush, E McMillan, D Attenborough, R Rens, W Ferguson-Smith, M Lefèvre, C Sharp, J Nicholas, K Ray, D Kube, M Reinhardt, R Pringle, T Taylor, J Jones, R Nixon, B Dacheux, J Niwa, H Sekita, Y Huang, X Stark, A Kheradpour, P Kellis, M Flicek, P Chen, Y Webber, C Hardison, R Nelson, J Hallsworth-Pepin, K Delehaunty, K Markovic, C Minx, P Feng, Y Kremitzki, C Mitreva, M Glasscock, J Wylie, T Wohldmann, P Thiru, P Nhan, M Pohl, C Smith, S Hou, S Nefedov, M de Jong, P Renfree, M Mardis, E Wilson, R Genome analysis of the platypus reveals unique signatures of evolution. |
| title | Genome analysis of the platypus reveals unique signatures of evolution. |
| title_full | Genome analysis of the platypus reveals unique signatures of evolution. |
| title_fullStr | Genome analysis of the platypus reveals unique signatures of evolution. |
| title_full_unstemmed | Genome analysis of the platypus reveals unique signatures of evolution. |
| title_short | Genome analysis of the platypus reveals unique signatures of evolution. |
| title_sort | genome analysis of the platypus reveals unique signatures of evolution |
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