The C-terminus of Apc does not influence intestinal adenoma development or progression

The C-terminus of Apc does not influence intestinal adenoma development or progression

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Adenomatous polyposis coli (APC) mutations are found in most colorectal tumours. These mutations are almost always protein-truncating, deleting both central domains that regulate Wnt signalling and C-terminal domains that interact with the cytoskeleton. The importance of Wnt dysregulation for colore...

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Bibliographic Details
Main Authors:	Lewis, A, Davis, H, Deheragoda, M, Pollard, P, Nye, E, Jeffery, R, Segditsas, S, East, P, Poulsom, R, Stamp, G, Wright, N, Tomlinson, I
Format:	Journal article
Language:	English
Published:	2012

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