The C-terminus of Apc does not influence intestinal adenoma development or progression
Adenomatous polyposis coli (APC) mutations are found in most colorectal tumours. These mutations are almost always protein-truncating, deleting both central domains that regulate Wnt signalling and C-terminal domains that interact with the cytoskeleton. The importance of Wnt dysregulation for colore...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal article |
| Jezik: | English |
| Izdano: |
2012
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