Synthesis of 3-fluoropyrrolidines and 4-fluoropyrrolidin-2-ones from allylic fluorides.

Synthesis of 3-fluoropyrrolidines and 4-fluoropyrrolidin-2-ones from allylic fluorides.

Various 3-fluoropyrrolidines and 4-fluoropyrrolidin-2-ones were prepared by 5-exo-trig iodocyclisation from allylic fluorides bearing a pending nitrogen nucleophile. These bench-stable precursors were made accessible upon electrophilic fluorination of the corresponding allylsilanes. The presence of...

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Bibliographic Details
Main Authors:	Combettes, L, Schuler, M, Patel, R, Bonillo, B, Odell, B, Thompson, A, Claridge, T, Gouverneur, V
Format:	Journal article
Language:	English
Published:	2012

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