Functional studies of BCL11A: characterization of the conserved BCL11A-XL splice variant and its interaction with BCL6 in nuclear paraspeckles of germinal center B cells.

Functional studies of BCL11A: characterization of the conserved BCL11A-XL splice variant and its interaction with BCL6 in nuclear paraspeckles of germinal center B cells.

BACKGROUND: Chromosomal aberrations of BCL11A at 2p16.1 have been reported in a variety of B-cell malignancies and its deficiency in mice leads to a profound block in B-cell development. RESULTS: Alternative pre-mRNA splicing of BCL11A produces multiple isoforms sharing a common N-terminus. The most...

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Bibliographic Details
Main Authors: Liu, H, Ippolito, G, Wall, J, Niu, T, Probst, L, Lee, B, Pulford, K, Banham, A, Stockwin, L, Shaffer, A, Staudt, L, Das, C, Dyer, M, Tucker, P
Format: Journal article
Language:English
Published: 2006

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